由于目前的解决方案都不产生一个元组，我将抛出:

temp3 = tuple(set(temp1) - set(temp2))

另外:

#edited using @Mark Byers idea. If you accept this one as answer, just accept his instead.
temp3 = tuple(x for x in temp1 if x not in set(temp2))

像其他在这个方向上得到答案的非元组一样，它保持了顺序

试试这个:

temp3 = set(temp1) - set(temp2)

这里有一个最简单情况的反答案。

这比上面那个做双向差分的要短，因为它只做了问题要求的事情:生成第一个列表中的东西的列表，而不是第二个列表中的东西。

from collections import Counter

lst1 = ['One', 'Two', 'Three', 'Four']
lst2 = ['One', 'Two']

c1 = Counter(lst1)
c2 = Counter(lst2)
diff = list((c1 - c2).elements())

或者，根据你的可读性偏好，它可以是一个不错的单行代码:

diff = list((Counter(lst1) - Counter(lst2)).elements())

输出:

['Three', 'Four']

请注意，如果您只是对其进行迭代，则可以删除list(…)调用。

因为这个解决方案使用计数器，所以相对于许多基于集合的答案，它可以正确地处理数量。例如，在这个输入中:

lst1 = ['One', 'Two', 'Two', 'Two', 'Three', 'Three', 'Four']
lst2 = ['One', 'Two']

输出结果为:

['Two', 'Two', 'Three', 'Three', 'Four']

我知道这个问题已经得到了很好的答案，但我希望使用numpy添加以下方法。

temp1 = ['One', 'Two', 'Three', 'Four']
temp2 = ['One', 'Two']

list(np.setdiff1d(temp1,temp2))

['Four', 'Three'] #Output

如果您想要更类似于变更集的东西……可以使用Counter

from collections import Counter

def diff(a, b):
  """ more verbose than needs to be, for clarity """
  ca, cb = Counter(a), Counter(b)
  to_add = cb - ca
  to_remove = ca - cb
  changes = Counter(to_add)
  changes.subtract(to_remove)
  return changes

lista = ['one', 'three', 'four', 'four', 'one']
listb = ['one', 'two', 'three']

In [127]: diff(lista, listb)
Out[127]: Counter({'two': 1, 'one': -1, 'four': -2})
# in order to go from lista to list b, you need to add a "two", remove a "one", and remove two "four"s

In [128]: diff(listb, lista)
Out[128]: Counter({'four': 2, 'one': 1, 'two': -1})
# in order to go from listb to lista, you must add two "four"s, add a "one", and remove a "two"

以下是@SuperNova的回答的修改版本

def get_diff(a: list, b: list) -> list:
    return list(set(a) ^ set(b))