由于目前的解决方案都不产生一个元组，我将抛出:

temp3 = tuple(set(temp1) - set(temp2))

另外:

#edited using @Mark Byers idea. If you accept this one as answer, just accept his instead.
temp3 = tuple(x for x in temp1 if x not in set(temp2))

像其他在这个方向上得到答案的非元组一样，它保持了顺序

我们可以计算交集减去列表并集:

temp1 = ['One', 'Two', 'Three', 'Four']
temp2 = ['One', 'Two', 'Five']

set(temp1+temp2)-(set(temp1)&set(temp2))

Out: set(['Four', 'Five', 'Three']) 

如果你想要递归的区别，我写了一个python包: https://github.com/seperman/deepdiff

安装

从PyPi安装:

pip install deepdiff

示例使用

进口

>>> from deepdiff import DeepDiff
>>> from pprint import pprint
>>> from __future__ import print_function # In case running on Python 2

同一对象返回空

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = t1
>>> print(DeepDiff(t1, t2))
{}

项目类型发生变化

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:"2", 3:3}
>>> pprint(DeepDiff(t1, t2), indent=2)
{ 'type_changes': { 'root[2]': { 'newtype': <class 'str'>,
                                 'newvalue': '2',
                                 'oldtype': <class 'int'>,
                                 'oldvalue': 2}}}

某项的值已更改

>>> t1 = {1:1, 2:2, 3:3}
>>> t2 = {1:1, 2:4, 3:3}
>>> pprint(DeepDiff(t1, t2), indent=2)
{'values_changed': {'root[2]': {'newvalue': 4, 'oldvalue': 2}}}

项目添加和/或删除

>>> t1 = {1:1, 2:2, 3:3, 4:4}
>>> t2 = {1:1, 2:4, 3:3, 5:5, 6:6}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff)
{'dic_item_added': ['root[5]', 'root[6]'],
 'dic_item_removed': ['root[4]'],
 'values_changed': {'root[2]': {'newvalue': 4, 'oldvalue': 2}}}

字符串的区别

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world"}}
>>> t2 = {1:1, 2:4, 3:3, 4:{"a":"hello", "b":"world!"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': { 'root[2]': {'newvalue': 4, 'oldvalue': 2},
                      "root[4]['b']": { 'newvalue': 'world!',
                                        'oldvalue': 'world'}}}

字符串差2

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world!\nGoodbye!\n1\n2\nEnd"}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n1\n2\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'values_changed': { "root[4]['b']": { 'diff': '--- \n'
                                                '+++ \n'
                                                '@@ -1,5 +1,4 @@\n'
                                                '-world!\n'
                                                '-Goodbye!\n'
                                                '+world\n'
                                                ' 1\n'
                                                ' 2\n'
                                                ' End',
                                        'newvalue': 'world\n1\n2\nEnd',
                                        'oldvalue': 'world!\n'
                                                    'Goodbye!\n'
                                                    '1\n'
                                                    '2\n'
                                                    'End'}}}

>>> 
>>> print (ddiff['values_changed']["root[4]['b']"]["diff"])
--- 
+++ 
@@ -1,5 +1,4 @@
-world!
-Goodbye!
+world
 1
 2
 End

类型变化

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":"world\n\n\nEnd"}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'type_changes': { "root[4]['b']": { 'newtype': <class 'str'>,
                                      'newvalue': 'world\n\n\nEnd',
                                      'oldtype': <class 'list'>,
                                      'oldvalue': [1, 2, 3]}}}

列表的区别

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3, 4]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{'iterable_item_removed': {"root[4]['b'][2]": 3, "root[4]['b'][3]": 4}}

差异2:

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'iterable_item_added': {"root[4]['b'][3]": 3},
  'values_changed': { "root[4]['b'][1]": {'newvalue': 3, 'oldvalue': 2},
                      "root[4]['b'][2]": {'newvalue': 2, 'oldvalue': 3}}}

列出差异忽略顺序或重复项:(使用与上面相同的字典)

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, 3]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 3, 2, 3]}}
>>> ddiff = DeepDiff(t1, t2, ignore_order=True)
>>> print (ddiff)
{}

包含字典的列表:

>>> t1 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:1, 2:2}]}}
>>> t2 = {1:1, 2:2, 3:3, 4:{"a":"hello", "b":[1, 2, {1:3}]}}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (ddiff, indent = 2)
{ 'dic_item_removed': ["root[4]['b'][2][2]"],
  'values_changed': {"root[4]['b'][2][1]": {'newvalue': 3, 'oldvalue': 1}}}

集:

>>> t1 = {1, 2, 8}
>>> t2 = {1, 2, 3, 5}
>>> ddiff = DeepDiff(t1, t2)
>>> pprint (DeepDiff(t1, t2))
{'set_item_added': ['root[3]', 'root[5]'], 'set_item_removed': ['root[8]']}

叫元组:

>>> from collections import namedtuple
>>> Point = namedtuple('Point', ['x', 'y'])
>>> t1 = Point(x=11, y=22)
>>> t2 = Point(x=11, y=23)
>>> pprint (DeepDiff(t1, t2))
{'values_changed': {'root.y': {'newvalue': 23, 'oldvalue': 22}}}

自定义对象:

>>> class ClassA(object):
...     a = 1
...     def __init__(self, b):
...         self.b = b
... 
>>> t1 = ClassA(1)
>>> t2 = ClassA(2)
>>> 
>>> pprint(DeepDiff(t1, t2))
{'values_changed': {'root.b': {'newvalue': 2, 'oldvalue': 1}}}

对象属性添加:

>>> t2.c = "new attribute"
>>> pprint(DeepDiff(t1, t2))
{'attribute_added': ['root.c'],
 'values_changed': {'root.b': {'newvalue': 2, 'oldvalue': 1}}}

现有的解决方案都提供了其中的一个或另一个:

比O(n*m)性能快。 保持输入列表的顺序。

但到目前为止，还没有一种解决方案兼而有之。如果你两者都想要，试试这个:

s = set(temp2)
temp3 = [x for x in temp1 if x not in s]

性能测试

import timeit
init = 'temp1 = list(range(100)); temp2 = [i * 2 for i in range(50)]'
print timeit.timeit('list(set(temp1) - set(temp2))', init, number = 100000)
print timeit.timeit('s = set(temp2);[x for x in temp1 if x not in s]', init, number = 100000)
print timeit.timeit('[item for item in temp1 if item not in temp2]', init, number = 100000)

结果:

4.34620224079 # ars' answer
4.2770634955  # This answer
30.7715615392 # matt b's answer

我提出的方法以及保持顺序也比集合减法(稍微)快，因为它不需要构造一个不必要的集合。如果第一个列表比第二个列表长得多，并且散列代价昂贵，那么性能差异将更加明显。下面是第二个测试:

init = '''
temp1 = [str(i) for i in range(100000)]
temp2 = [str(i * 2) for i in range(50)]
'''

结果:

11.3836875916 # ars' answer
3.63890368748 # this answer (3 times faster!)
37.7445402279 # matt b's answer

这里有一个最简单情况的反答案。

这比上面那个做双向差分的要短，因为它只做了问题要求的事情:生成第一个列表中的东西的列表，而不是第二个列表中的东西。

from collections import Counter

lst1 = ['One', 'Two', 'Three', 'Four']
lst2 = ['One', 'Two']

c1 = Counter(lst1)
c2 = Counter(lst2)
diff = list((c1 - c2).elements())

或者，根据你的可读性偏好，它可以是一个不错的单行代码:

diff = list((Counter(lst1) - Counter(lst2)).elements())

输出:

['Three', 'Four']

请注意，如果您只是对其进行迭代，则可以删除list(…)调用。

因为这个解决方案使用计数器，所以相对于许多基于集合的答案，它可以正确地处理数量。例如，在这个输入中:

lst1 = ['One', 'Two', 'Two', 'Two', 'Three', 'Three', 'Four']
lst2 = ['One', 'Two']

输出结果为:

['Two', 'Two', 'Three', 'Three', 'Four']

这里有一个简单的方法来区分两个列表(无论内容是什么)，你可以得到如下所示的结果:

>>> from sets import Set
>>>
>>> l1 = ['xvda', False, 'xvdbb', 12, 'xvdbc']
>>> l2 = ['xvda', 'xvdbb', 'xvdbc', 'xvdbd', None]
>>>
>>> Set(l1).symmetric_difference(Set(l2))
Set([False, 'xvdbd', None, 12])

希望这对你有所帮助。