Yes, I read all the answers. However, if you are me and have been pulling out all of what's left of your hair, then try checking the \bin folder. Like most proj files might have several configurations grouped under the XML element PropertyGroup, then I changed the OutputPath value from 'bin\Debug' to remove the '\Debug' part and Rebuild. This placed the files in the \bin folder allowing the Express IIS to find and load the build. I am left wondering what is the correct way to manage these different builds so that a local debug deploy is able to find and load the target environment.

我只是在一个MVC5应用程序上遇到了这个问题，没有什么对我有用。这发生在我试图将SVN还原到项目的旧版本之后。

我必须删除Global. asax.cs，然后通过右键单击项目->添加新项目-> Global来添加一个新的项目。asax和THAT最终解决了它。

只是觉得也许能帮到别人。

I faced the problem in VS 2017 out of no where, took my whole day going through 100 of solutions any of these didnt work. I then took my whole solution and started it on different machine having VS 2017 installation.. IT FINALLY WORKED. Than reinstalled VS 2017 on the original one and it started running on that too. I strongly recommend you try your solution on a different machine before wasting much time to debug it, bcz it is a BUG in VS 2017 as it seemed for me, have reported same to VS TEAM. Hope this helps any one in grief. Cheers.

无法加载项目的错误 首先修复你的错误，重建项目后，它的工作

清空bin文件夹。构建所有依赖类库并在主项目中引用它们，然后构建完整的解决方案。

源

我用很简单的方法修好了它。你所要做的就是删除ProjectName\bin文件夹中的所有文件，然后从Visual studio顶部菜单栏Build->Rebuild Solution再次重建项目，你就完成了。现在试着运行这个项目。这个过程在Visual Studio 2022中为我工作。