var search = "world";
var replacement = "csharp";
string result = Regex.Replace(
    stringToLookInto,
    Regex.Escape(search), 
    replacement.Replace("$","$$"), 
    RegexOptions.IgnoreCase
);

正则表达式。如果您依赖于可能包含Regex语言元素的用户输入，那么Escape是有用的

更新

多亏了注释，您实际上不必转义替换字符串。

下面是一个测试代码的小工具:

using System;
using System.Text.RegularExpressions;           
public class Program
{
    public static void Main()
    {

        var tests = new[] {
            new { Input="abcdef", Search="abc", Replacement="xyz", Expected="xyzdef" },
            new { Input="ABCdef", Search="abc", Replacement="xyz", Expected="xyzdef" },
            new { Input="A*BCdef", Search="a*bc", Replacement="xyz", Expected="xyzdef" },
            new { Input="abcdef", Search="abc", Replacement="x*yz", Expected="x*yzdef" },       
            new { Input="abcdef", Search="abc", Replacement="$", Expected="$def" },
        };


        foreach(var test in tests){
            var result = ReplaceCaseInsensitive(test.Input, test.Search, test.Replacement);

            Console.WriteLine(
                "Success: {0}, Actual: {1}, {2}",
                result == test.Expected,
                result,
                test
            );

        }


    }

    private static string ReplaceCaseInsensitive(string input, string search, string replacement){
        string result = Regex.Replace(
            input,
            Regex.Escape(search), 
            replacement.Replace("$","$$"), 
            RegexOptions.IgnoreCase
        );
        return result;
    }
}

它的输出是:

Success: True, Actual: xyzdef, { Input = abcdef, Search = abc, Replacement = xyz, Expected = xyzdef } 
Success: True, Actual: xyzdef, { Input = ABCdef, Search = abc, Replacement = xyz, Expected = xyzdef }
Success: True, Actual: xyzdef, { Input = A*BCdef, Search = a*bc, Replacement = xyz, Expected = xyzdef } 
Success: True, Actual: x*yzdef, { Input = abcdef, Search = abc, Replacement = x*yz, Expected = x*yzdef} 
Success: True, Actual: $def, { Input = abcdef, Search = abc, Replacement = $, Expected = $def }

你可以使用Regex并执行不区分大小写的替换:

class Program
{
    static void Main()
    {
        string input = "hello WoRlD";
        string result = 
           Regex.Replace(input, "world", "csharp", RegexOptions.IgnoreCase);
        Console.WriteLine(result); // prints "hello csharp"
    }
}

使用@Georgy Batalov解决方案时，我在使用以下示例时遇到了一个问题

string original = "blah,DC=bleh,DC=blih,DC=bloh,DC=com"; 字符串替换=原始。ReplaceIgnoreCase (DC =”、“。”)

下面是我如何重写他的扩展

public static string ReplaceIgnoreCase(this string source, string oldVale, 
string newVale)
    {
        if (source.IsNullOrEmpty() || oldVale.IsNullOrEmpty())
            return source;

        var stringBuilder = new StringBuilder();
        string result = source;

        int index = result.IndexOf(oldVale, StringComparison.InvariantCultureIgnoreCase);
        bool initialRun = true;

        while (index >= 0)
        {
            string substr = result.Substring(0, index);
            substr = substr + newVale;
            result = result.Remove(0, index);
            result = result.Remove(0, oldVale.Length);

            stringBuilder.Append(substr);

            index = result.IndexOf(oldVale, StringComparison.InvariantCultureIgnoreCase);
        }

        if (result.Length > 0)
        {
            stringBuilder.Append(result);
        }

        return stringBuilder.ToString();
    }

你可以用微软。VisualBasic命名空间来查找这个帮助函数:

Replace(sourceString, "replacethis", "withthis", , , CompareMethod.Text)

另一种方法是使用StringComparison选项忽略String.Replace()中的大小写敏感性。CurrentCultureIgnoreCase

string.Replace("World", "csharp", StringComparison.CurrentCultureIgnoreCase)

使用这个，测试和100%工作!

VB。网

Dim myString As String
Dim oldValue As String
Dim newValue As String

myString = Form1.TextBox1.Text
oldValue = TextBox1.Text
newValue = TextBox2.Text

Dim working As String = myString
Dim index As Integer = working.IndexOf(oldValue, StringComparison.CurrentCultureIgnoreCase)

While index <> -1
    working = working.Remove(index, oldValue.Length)
    working = working.Insert(index, newValue)
    index = index + newValue.Length
    index = working.IndexOf(oldValue, index, StringComparison.CurrentCultureIgnoreCase)
    Form1.TextBox1.Text = working
End While

为c#

private void Button2_Click(System.Object sender, System.EventArgs e)
{
    string myString;
    string oldValue;
    string newValue;

    myString = Form1.TextBox1.Text;
    oldValue = TextBox1.Text;
    newValue = TextBox2.Text;

    string working = myString;
    int index = working.IndexOf(oldValue, StringComparison.CurrentCultureIgnoreCase);

    while (index != -1)
    {
        working = working.Remove(index, oldValue.Length);
        working = working.Insert(index, newValue);
        index = index + newValue.Length;
        index = working.IndexOf(oldValue, index, StringComparison.CurrentCultureIgnoreCase);
        Form1.TextBox1.Text = working;
    }
}