为了消除单行标签的垂直填充，我做了:

// I have a category method setFrameHeight; you'll likely need to modify the frame.
[label setFrameHeight:font.pointSize];

或者，不带类别，使用:

CGRect frame = label.frame;
frame.size.height = font.pointSize;
label.frame = frame;

在Swift 3中，你可以通过创建UILabel的子类来达到你想要的效果。在这个子类中，你必须添加一个UIEdgeInsets属性，并覆盖drawText(In:)方法，intrinsicContentSize属性(用于自动布局代码)和/或sizeThatFits(_:)方法(用于Springs和Struts代码)。

import UIKit

class PaddingLabel: UILabel {

    let padding: UIEdgeInsets

    // Create a new PaddingLabel instance programamtically with the desired insets
    required init(padding: UIEdgeInsets = UIEdgeInsets(top: 0, left: 10, bottom: 0, right: 10)) {
        self.padding = padding
        super.init(frame: CGRect.zero)
    }

    // Create a new PaddingLabel instance programamtically with default insets
    override init(frame: CGRect) {
        padding = UIEdgeInsets.zero // set desired insets value according to your needs
        super.init(frame: frame)
    }

    // Create a new PaddingLabel instance from Storyboard with default insets
    required init?(coder aDecoder: NSCoder) {
        padding = UIEdgeInsets.zero // set desired insets value according to your needs
        super.init(coder: aDecoder)
    }

    override func drawText(in rect: CGRect) {
        super.drawText(in: UIEdgeInsetsInsetRect(rect, padding))
    }

    // Override `intrinsicContentSize` property for Auto layout code
    override var intrinsicContentSize: CGSize {
        let superContentSize = super.intrinsicContentSize
        let width = superContentSize.width + padding.left + padding.right
        let height = superContentSize.height + padding.top + padding.bottom
        return CGSize(width: width, height: height)
    }

    // Override `sizeThatFits(_:)` method for Springs & Struts code
    override func sizeThatFits(_ size: CGSize) -> CGSize {
        let superSizeThatFits = super.sizeThatFits(size)
        let width = superSizeThatFits.width + padding.left + padding.right
        let heigth = superSizeThatFits.height + padding.top + padding.bottom
        return CGSize(width: width, height: heigth)
    }

}

下面的例子展示了如何在UIViewController中使用PaddingLabel实例:

import UIKit

class ViewController: UIViewController {

    @IBOutlet weak var storyboardAutoLayoutLabel: PaddingLabel!
    let autoLayoutLabel = PaddingLabel(padding: UIEdgeInsets(top: 20, left: 40, bottom: 20, right: 40))
    let springsAndStructsLabel = PaddingLabel(frame: CGRect.zero)
    var textToDisplay = "Lorem ipsum dolor sit er elit lamet."

    override func viewDidLoad() {
        super.viewDidLoad()

        // Set autoLayoutLabel
        autoLayoutLabel.text = textToDisplay
        autoLayoutLabel.backgroundColor = .red
        autoLayoutLabel.translatesAutoresizingMaskIntoConstraints = false
        view.addSubview(autoLayoutLabel)
        autoLayoutLabel.leadingAnchor.constraint(equalTo: view.leadingAnchor, constant: 30).isActive = true
        autoLayoutLabel.centerYAnchor.constraint(equalTo: view.centerYAnchor).isActive = true

        // Set springsAndStructsLabel
        springsAndStructsLabel.text = textToDisplay
        springsAndStructsLabel.backgroundColor = .green
        view.addSubview(springsAndStructsLabel)
        springsAndStructsLabel.frame.origin = CGPoint(x: 30, y: 90)
        springsAndStructsLabel.sizeToFit()

        // Set storyboardAutoLayoutLabel
        storyboardAutoLayoutLabel.text = textToDisplay
        storyboardAutoLayoutLabel.backgroundColor = .blue
    }

    // Link this IBAction to a UIButton or a UIBarButtonItem in Storyboard
    @IBAction func updateLabelText(_ sender: Any) {
        textToDisplay = textToDisplay == "Lorem ipsum dolor sit er elit lamet." ? "Lorem ipsum." : "Lorem ipsum dolor sit er elit lamet."

        // autoLayoutLabel
        autoLayoutLabel.text = textToDisplay

        // springsAndStructsLabel
        springsAndStructsLabel.text = textToDisplay
        springsAndStructsLabel.sizeToFit()

        // storyboardAutoLayoutLabel
        storyboardAutoLayoutLabel.text = textToDisplay
    }

}

对于Xamarin用户(使用统一API):

class UIMarginLabel : UILabel
{
    public UIMarginLabel()
    {
    }

    public UIMarginLabel( CGRect frame ) : base( frame )
    {
    }

    public UIEdgeInsets Insets { get; set; }

    public override void DrawText( CGRect rect )
    {
        base.DrawText( Insets.InsetRect( rect ) );
    }
}

对于那些使用原始MonoTouch API的人:

public class UIMarginLabel : UILabel
{
    public UIEdgeInsets Insets { get; set; }

    public UIMarginLabel() : base()
    {
        Insets = new UIEdgeInsets(0, 0, 0, 0);
    }
    public UIMarginLabel(RectangleF frame) : base(frame)
    {
        Insets = new UIEdgeInsets(0, 0, 0, 0);
    }

    public override void DrawText(RectangleF frame)
    {
        base.DrawText(new RectangleF(
            frame.X + Insets.Left,
            frame.Y + Insets.Top,
            frame.Width - Insets.Left - Insets.Right,
            frame.Height - Insets.Top - Insets.Bottom));
    }
}

不要编码，Xcode !

比起使用UILabel来解决这个问题，我建议你去看看UIButton。它提供了开箱即用的功能，可以在大小检查器中设置内容插入(上、左、下、右)。设置所需的边距，然后在Xcode中禁用按钮，完成。

我认为UILabel类没有设置边距的方法。为什么不把标签的位置设置在需要的位置?

见下面的代码:

UILabel *label = [[UILabel alloc] init];
label.text = @"This is label";
label.frame = CGRectMake(0,0,100,100);

如果来自接口构建器，则按以下方式定位Label:

yourLabel.frame = CGRectMake(0,0,100,100);

可以使用https://github.com/mattt/TTTAttributedLabel代替UILabel

BITAttributedLabel *label = [BITAttributedLabel new];
label.font = font;
label.text = @"hello";
label.textInsets = UIEdgeInsetsMake(10, 10, 10, 10);
[label sizeToFit];