这个答案只是扩展了@Andy Hayden的答案，使其能够适应数值字段为nan的情况，并将其包装成一个函数。

import pandas as pd
import numpy as np


def diff_pd(df1, df2):
    """Identify differences between two pandas DataFrames"""
    assert (df1.columns == df2.columns).all(), \
        "DataFrame column names are different"
    if any(df1.dtypes != df2.dtypes):
        "Data Types are different, trying to convert"
        df2 = df2.astype(df1.dtypes)
    if df1.equals(df2):
        return None
    else:
        # need to account for np.nan != np.nan returning True
        diff_mask = (df1 != df2) & ~(df1.isnull() & df2.isnull())
        ne_stacked = diff_mask.stack()
        changed = ne_stacked[ne_stacked]
        changed.index.names = ['id', 'col']
        difference_locations = np.where(diff_mask)
        changed_from = df1.values[difference_locations]
        changed_to = df2.values[difference_locations]
        return pd.DataFrame({'from': changed_from, 'to': changed_to},
                            index=changed.index)

所以对于你的数据(稍微编辑一下，在分数列中有一个NaN):

import sys
if sys.version_info[0] < 3:
    from StringIO import StringIO
else:
    from io import StringIO

DF1 = StringIO("""id   Name   score                    isEnrolled           Comment
111  Jack   2.17                     True                 "He was late to class"
112  Nick   1.11                     False                "Graduated"
113  Zoe    NaN                     True                  " "
""")
DF2 = StringIO("""id   Name   score                    isEnrolled           Comment
111  Jack   2.17                     True                 "He was late to class"
112  Nick   1.21                     False                "Graduated"
113  Zoe    NaN                     False                "On vacation" """)
df1 = pd.read_table(DF1, sep='\s+', index_col='id')
df2 = pd.read_table(DF2, sep='\s+', index_col='id')
diff_pd(df1, df2)

输出:

                from           to
id  col                          
112 score       1.11         1.21
113 isEnrolled  True        False
    Comment           On vacation

扩展@cge的答案，这对于结果的可读性来说非常酷:

a[a != b][np.any(a != b, axis=1)].join(pd.DataFrame('a<->b', index=a.index, columns=['a<=>b'])).join(
        b[a != b][np.any(a != b, axis=1)]
        ,rsuffix='_b', how='outer'
).fillna('')

完整的演示示例:

import numpy as np, pandas as pd

a = pd.DataFrame(np.random.randn(7,3), columns=list('ABC'))
b = a.copy()
b.iloc[0,2] = np.nan
b.iloc[1,0] = 7
b.iloc[3,1] = 77
b.iloc[4,2] = 777

a[a != b][np.any(a != b, axis=1)].join(pd.DataFrame('a<->b', index=a.index, columns=['a<=>b'])).join(
        b[a != b][np.any(a != b, axis=1)]
        ,rsuffix='_b', how='outer'
).fillna('')

结果:样本

在线演示

import pandas as pd
import io

texts = ['''\
id   Name   score                    isEnrolled                        Comment
111  Jack   2.17                     True                 He was late to class
112  Nick   1.11                     False                           Graduated
113  Zoe    4.12                     True       ''',

         '''\
id   Name   score                    isEnrolled                        Comment
111  Jack   2.17                     True                 He was late to class
112  Nick   1.21                     False                           Graduated
113  Zoe    4.12                     False                         On vacation''']


df1 = pd.read_fwf(io.StringIO(texts[0]), widths=[5,7,25,21,20])
df2 = pd.read_fwf(io.StringIO(texts[1]), widths=[5,7,25,21,20])
df = pd.concat([df1,df2]) 

print(df)
#     id  Name  score isEnrolled               Comment
# 0  111  Jack   2.17       True  He was late to class
# 1  112  Nick   1.11      False             Graduated
# 2  113   Zoe   4.12       True                   NaN
# 0  111  Jack   2.17       True  He was late to class
# 1  112  Nick   1.21      False             Graduated
# 2  113   Zoe   4.12      False           On vacation

df.set_index(['id', 'Name'], inplace=True)
print(df)
#           score isEnrolled               Comment
# id  Name                                        
# 111 Jack   2.17       True  He was late to class
# 112 Nick   1.11      False             Graduated
# 113 Zoe    4.12       True                   NaN
# 111 Jack   2.17       True  He was late to class
# 112 Nick   1.21      False             Graduated
# 113 Zoe    4.12      False           On vacation

def report_diff(x):
    return x[0] if x[0] == x[1] else '{} | {}'.format(*x)

changes = df.groupby(level=['id', 'Name']).agg(report_diff)
print(changes)

打印

                score    isEnrolled               Comment
id  Name                                                 
111 Jack         2.17          True  He was late to class
112 Nick  1.11 | 1.21         False             Graduated
113 Zoe          4.12  True | False     nan | On vacation

下面是另一种使用选择和合并的方法:

In [6]: # first lets create some dummy dataframes with some column(s) different
   ...: df1 = pd.DataFrame({'a': range(-5,0), 'b': range(10,15), 'c': range(20,25)})
   ...: df2 = pd.DataFrame({'a': range(-5,0), 'b': range(10,15), 'c': [20] + list(range(101,105))})


In [7]: df1
Out[7]:
   a   b   c
0 -5  10  20
1 -4  11  21
2 -3  12  22
3 -2  13  23
4 -1  14  24


In [8]: df2
Out[8]:
   a   b    c
0 -5  10   20
1 -4  11  101
2 -3  12  102
3 -2  13  103
4 -1  14  104


In [10]: # make condition over the columns you want to comapre
    ...: condition = df1['c'] != df2['c']
    ...:
    ...: # select rows from each dataframe where the condition holds
    ...: diff1 = df1[condition]
    ...: diff2 = df2[condition]


In [11]: # merge the selected rows (dataframes) with some suffixes (optional)
    ...: diff1.merge(diff2, on=['a','b'], suffixes=('_before', '_after'))
Out[11]:
   a   b  c_before  c_after
0 -4  11        21      101
1 -3  12        22      102
2 -2  13        23      103
3 -1  14        24      104

以下是来自Jupyter的截图:

突出显示两个数据框架之间的差异

可以使用DataFrame样式属性来突出显示有差异的单元格的背景颜色。

使用原始问题中的示例数据

第一步是用concat函数水平连接dataframe，并用keys参数区分每一帧:

df_all = pd.concat([df.set_index('id'), df2.set_index('id')], 
                   axis='columns', keys=['First', 'Second'])
df_all

交换列级别并将相同的列名放在彼此旁边可能更容易:

df_final = df_all.swaplevel(axis='columns')[df.columns[1:]]
df_final

现在，很容易看出不同的框架。但是，我们可以进一步使用style属性来突出显示不同的单元格。我们定义了一个自定义函数来实现这一点，您可以在本部分文档中看到。

def highlight_diff(data, color='yellow'):
    attr = 'background-color: {}'.format(color)
    other = data.xs('First', axis='columns', level=-1)
    return pd.DataFrame(np.where(data.ne(other, level=0), attr, ''),
                        index=data.index, columns=data.columns)

df_final.style.apply(highlight_diff, axis=None)

这将突出显示两者都有缺失值的单元格。您可以填充它们或提供额外的逻辑，这样它们就不会被突出显示。

使用concat和drop_duplicate的不同方法:

import sys
if sys.version_info[0] < 3:
    from StringIO import StringIO
else:
    from io import StringIO
import pandas as pd

DF1 = StringIO("""id   Name   score                    isEnrolled           Comment
111  Jack   2.17                     True                 "He was late to class"
112  Nick   1.11                     False                "Graduated"
113  Zoe    NaN                     True                  " "
""")
DF2 = StringIO("""id   Name   score                    isEnrolled           Comment
111  Jack   2.17                     True                 "He was late to class"
112  Nick   1.21                     False                "Graduated"
113  Zoe    NaN                     False                "On vacation" """)

df1 = pd.read_table(DF1, sep='\s+', index_col='id')
df2 = pd.read_table(DF2, sep='\s+', index_col='id')
#%%
dictionary = {1:df1,2:df2}
df=pd.concat(dictionary)
df.drop_duplicates(keep=False)

输出:

       Name  score isEnrolled      Comment
  id                                      
1 112  Nick   1.11      False    Graduated
  113   Zoe    NaN       True             
2 112  Nick   1.21      False    Graduated
  113   Zoe    NaN      False  On vacation