Swift 4+方法:

1)设置UIScrollView的上、下、左、右边缘为0

2)在UIScrollView中添加一个UIView，并设置顶部、底部、前边距和尾随边距为0(等于UIScrollView的边距)。

3)最重要的部分是设置宽度和高度，其中高度约束的优先级应该低。

private func setupConstraints() {

    // Constraints for scrollView
    scrollView.topAnchor.constraint(equalTo: view.topAnchor).isActive = true
    scrollView.leadingAnchor.constraint(equalTo: view.leadingAnchor).isActive = true
    scrollView.trailingAnchor.constraint(equalTo: view.trailingAnchor).isActive = true
    scrollView.bottomAnchor.constraint(equalTo: view.bottomAnchor).isActive = true

    // Constraints for containerView
    containerView.topAnchor.constraint(equalTo: scrollView.topAnchor).isActive = true
    containerView.bottomAnchor.constraint(equalTo: scrollView.bottomAnchor).isActive = true
    containerView.leadingAnchor.constraint(equalTo: scrollView.leadingAnchor).isActive = true
    containerView.trailingAnchor.constraint(equalTo: scrollView.trailingAnchor).isActive = true
    containerView.widthAnchor.constraint(equalTo: scrollView.widthAnchor).isActive = true

    let heightConstraint = containerView.heightAnchor.constraint(equalTo: scrollView.heightAnchor)
    heightConstraint.priority = UILayoutPriority(rawValue: 250)
    heightConstraint.isActive = true
}

使用contentView (UView)作为容器在UIScrollView，坚持边缘(上，下，后，前)的superview (UIScrollView)和contentView应该有等宽和等高的superview。这些都是约束条件。方法的调用:

-(void)viewDidLayoutSubviews
{
    [super viewDidLayoutSubviews];
    self.scrollView.contentSize = self.contentView.frame.size;
}

为我解决了问题。

This error took me a while to track down, initially I tried pinning the ScrollView's size but the error message clearly says "content size". I made sure everything I pinned from the top of the ScrollView was also pinned to the bottom. That way the ScrollView can calculate its content height by finding the height of all the objects & constraints. This solved the ambiguous content height, the width is pretty similar... Initially I had most things X centered in the ScrollView, but I had to also pin the objects to the side of the ScrollView. I don't like this because the iPhone6 might have a wider screen but it will remove the 'ambiguous content width' error.

正如在之前的回答中提到的，你应该在滚动视图中添加一个自定义视图:

将所有子视图添加到内容视图。 在某些时候，你会看到滚动内容视图有模糊的内容大小警告，你应该选择内容视图并单击“解决自动布局问题”按钮(在IB布局的右下角)，并选择“添加缺少的约束”选项。

从现在开始，当你运行项目时，滚动视图将自动更新它的内容大小，不需要额外的代码。

import UIKit

class ViewController: UIViewController {

    //
    let scrollView: UIScrollView = {
        
        let sv = UIScrollView()
        sv.translatesAutoresizingMaskIntoConstraints = false
        return sv
    }()
    
    let lipsumLbl: UILabel = { // you can use here any of your subview
        
        let lbl = UILabel()
        lbl.translatesAutoresizingMaskIntoConstraints = false
        lbl.text = """
        Lorem ipsum dolor sit amet, consectetur adipiscing elit. Fusce eleifend nisi sit amet mi aliquet, ut efficitur risus pellentesque. Phasellus nulla justo, scelerisque ut libero id, aliquet ullamcorper lectus. Integer id iaculis nibh. Duis feugiat mi vitae magna tincidunt, vitae consequat dui tempor. Donec blandit urna nec urna volutpat, sit amet sagittis massa fringilla. Pellentesque luctus erat nec dui luctus, sed maximus urna fermentum. Nullam purus nibh, cursus vel ex nec, pulvinar lobortis leo. Proin ac libero rhoncus, bibendum lorem sed, congue sapien. Donec commodo, est non mollis malesuada, nisi massa tempus ipsum, a varius quam lorem vitae nunc.
        
        Cras scelerisque nisi dolor, in gravida ex ornare a. Interdum et malesuada fames ac ante ipsum primis in faucibus. Maecenas vitae nisl id erat sollicitudin accumsan sit amet viverra sapien. Etiam scelerisque vulputate ante. Donec magna nibh, pharetra sed pretium ac, feugiat sit amet mi. Vestibulum in ipsum vitae dui vehicula pulvinar eget ut lectus. Fusce sagittis a elit ac elementum. Fusce iaculis nunc odio, at fermentum dolor varius et. Suspendisse consectetur congue massa non gravida. Sed id elit vitae nulla aliquam euismod. Pellentesque accumsan risus dolor, eu cursus nibh semper id.
        
        Vestibulum vel tortor tellus. Suspendisse potenti. Pellentesque id sapien eu augue placerat dictum. Fusce tempus ligula at diam lacinia congue in ut metus. Maecenas volutpat tellus in tellus maximus imperdiet. Integer dignissim condimentum lorem, id luctus nisi maximus at. Nulla pretium, est sit amet mollis eleifend, tellus nulla viverra dolor, ac feugiat massa risus a lectus. Pellentesque ut pulvinar urna, blandit gravida ipsum. Nullam volutpat arcu nec fringilla auctor. Integer egestas enim commodo, faucibus neque ac, rutrum magna. Vivamus tincidunt rutrum auctor. Cras at rutrum felis. Fusce elementum lorem ut pharetra venenatis.
        """
        lbl.textColor = .darkGray
        lbl.font = UIFont.systemFont(ofSize: 16)
        lbl.numberOfLines = 0
        return lbl
    }()
    
    //======================================================================//
    //
    // MARK:- viewDidLoad
    //
    override func viewDidLoad() {
        super.viewDidLoad()
        
        setupViews()
        setupAutoLayout()
    }
    
    func setupViews() {
        
        title = "ScrollView Demo"
        view.backgroundColor = .white
        view.addSubview(scrollView)
        scrollView.addSubview(lipsumLbl)
    }
    
    func setupAutoLayout() {
        
        scrollView.leftAnchor.constraint(equalTo: view.leftAnchor).isActive = true
        scrollView.rightAnchor.constraint(equalTo: view.rightAnchor).isActive = true
        scrollView.topAnchor.constraint(equalTo: view.topAnchor).isActive = true
        scrollView.bottomAnchor.constraint(equalTo: view.bottomAnchor).isActive = true
        
        lipsumLbl.topAnchor.constraint(equalTo: scrollView.topAnchor).isActive = true
        lipsumLbl.leftAnchor.constraint(equalTo: view.leftAnchor).isActive = true
        lipsumLbl.rightAnchor.constraint(equalTo: view.rightAnchor).isActive = true
        lipsumLbl.bottomAnchor.constraint(equalTo: scrollView.bottomAnchor).isActive = true
    }
}

输出:

我也有同样的问题。取消这个复选框。因为您是在代码中设置内容大小。