你可以试试

var strArr = str.split("");

strArr[0] = 'h';

str = strArr.join("");

我做了一个类似于你问的函数，它检查字符串中的字符是否在不允许字符数组中如果是它就用"

    var validate = function(value){
        var notAllowed = [";","_",">","<","'","%","$","&","/","|",":","=","*"];
        for(var i=0; i<value.length; i++){
            if(notAllowed.indexOf(value.charAt(i)) > -1){
               value = value.replace(value.charAt(i), "");
               value = validate(value);
            }
       }
      return value;
   }

你不能。取位置前后的字符并连接成一个新字符串:

var s = "Hello world";
var index = 3;
s = s.substring(0, index) + 'x' + s.substring(index + 1);

我用负下标的安全方法

/**
 * @param {string} str 
 * @param {number} index 
 * @param {string} replacement 
 * @returns {string}
 */
static replaceAt (str, index, replacement)
{
    if (index < 0) index = str.length + index
    if (index < 0 || index >= str.length) throw new Error(`Index (${index}) out of bounds "${str}"`)
    return str.substring(0, index) + replacement + str.substring(index + 1)
}

像这样使用它:

replaceAt('my string', -1, 'G') // 'my strinG'
replaceAt('my string', 2, 'yy') // 'myyystring'
replaceAt('my string', 22, 'yy') // Uncaught Error: Index (22) out of bounds "my string"

这里的方法很复杂。 我会这样做:

var myString = "this is my string";
myString = myString.replace(myString.charAt(number goes here), "insert replacement here");

这很简单。

可以使用以下函数替换字符串特定位置的字符或字符串。使用String.prototype.replaceAllMatches()函数替换以下所有匹配案例。

String.prototype.replaceMatch = function(matchkey, replaceStr, matchIndex) {
    var retStr = this, repeatedIndex = 0;
    for (var x = 0; (matchkey != null) && (retStr.indexOf(matchkey) > -1); x++) {
        if (repeatedIndex == 0 && x == 0) {
            repeatedIndex = retStr.indexOf(matchkey);
        } else { // matchIndex > 0
            repeatedIndex = retStr.indexOf(matchkey, repeatedIndex + 1);
        }
        if (x == matchIndex) {
            retStr = retStr.substring(0, repeatedIndex) + replaceStr + retStr.substring(repeatedIndex + (matchkey.length));
            matchkey = null; // To break the loop.
        }
    }
    return retStr;
};

测试:

var str = "yash yas $dfdas.**";

console.log('Index Matched replace : ', str.replaceMatch('as', '*', 2) );
console.log('Index Matched replace : ', str.replaceMatch('y', '~', 1) );

输出:

Index Matched replace :  yash yas $dfd*.**
Index Matched replace :  yash ~as $dfdas.**