感谢阿姆贾德·马萨德，他激励了我。

我有以下解决方案，似乎在IE9, FF和Chrome和代码很短(没有复杂的闭包和横向子东西):

    DIV.onmouseout=function(e){
        // check and loop relatedTarget.parentNode
        // ignore event triggered mouse overing any child element or leaving itself
        var obj=e.relatedTarget;
        while(obj!=null){
            if(obj==this){
                return;
            }
            obj=obj.parentNode;
        }
        // now perform the actual action you want to do only when mouse is leaving the DIV
    }

function onMouseOut(event) {
        //this is the original element the event handler was assigned to
        var e = event.toElement || event.relatedTarget;
        if (e.parentNode == this || e == this) {
           return;
        }
    alert('MouseOut');
    // handle mouse event here!
}



document.getElementById('parent').addEventListener('mouseout',onMouseOut,true);

我做了一个快速的JsFiddle演示，所有的CSS和HTML需要，检查它…

编辑固定链接跨浏览器支持http://jsfiddle.net/RH3tA/9/

注意，这只检查直接的父元素，如果父div有嵌套的子元素，那么你必须以某种方式遍历元素的父元素，寻找“原始元素”

编辑嵌套子的示例

编辑修复希望跨浏览器

function makeMouseOutFn(elem){
    var list = traverseChildren(elem);
    return function onMouseOut(event) {
        var e = event.toElement || event.relatedTarget;
        if (!!~list.indexOf(e)) {
            return;
        }
        alert('MouseOut');
        // handle mouse event here!
    };
}

//using closure to cache all child elements
var parent = document.getElementById("parent");
parent.addEventListener('mouseout',makeMouseOutFn(parent),true);

//quick and dirty DFS children traversal, 
function traverseChildren(elem){
    var children = [];
    var q = [];
    q.push(elem);
    while (q.length > 0) {
      var elem = q.pop();
      children.push(elem);
      pushAll(elem.children);
    }
    function pushAll(elemArray){
      for(var i=0; i < elemArray.length; i++) {
        q.push(elemArray[i]);
      }
    }
    return children;
}

和一个新的JSFiddle, EDIT更新链接

有两种方法可以处理这个问题。

1)检查事件。目标结果在你的回调，看看它是否匹配你的父div

var g_ParentDiv;

function OnMouseOut(event) {
    if (event.target != g_ParentDiv) {
        return;
    }
    // handle mouse event here!
};


window.onload = function() {
    g_ParentDiv = document.getElementById("parentdiv");
    g_ParentDiv.onmouseout = OnMouseOut;
};

<div id="parentdiv">
    <img src="childimage.jpg" id="childimg" />
</div>

2)或者使用事件捕获和调用事件。回调函数中的stopPropagation

var g_ParentDiv;

function OnMouseOut(event) {

    event.stopPropagation(); // don't let the event recurse into children

    // handle mouse event here!
};


window.onload = function() {
    g_ParentDiv = document.getElementById("parentdiv");
    g_ParentDiv.addEventListener("mouseout", OnMouseOut, true); // pass true to enable event capturing so parent gets event callback before children
};

<div id="parentdiv">
    <img src="childimage.jpg" id="childimg" />
</div>

香草也可以用这种方法

document.querySelector('.product_items') && document.querySelector('.product_items').addEventListener('mouseleave', () => updateCart()) const updateCart = () => { let total = 0; document.querySelectorAll('input') && document.querySelectorAll('input').forEach(item => total += +item.value) document.getElementById('total').innerHTML = total } <div class="product_items"> <div class="product_item"> <div class="product_name"> </div> <div class="multiply__btn"> <button type="button">-</button> <input name="test" type="text"> <button type="button">+</button> </div> </div> <div class="product_item"> <div class="product_name"> </div> <div class="multiply__btn"> <button type="button">-</button> <input name="test" type="text"> <button type="button">+</button> </div> </div> <div class="product_item"> <div class="product_name"> </div> <div class="multiply__btn"> <button type="button">-</button> <input name="test" type="text"> <button type="button">+</button> </div> </div> </div> <div id="total"></div>

var elem = $('#some-id');
elem.mouseover(function () {
   // Some code here
}).mouseout(function (event) {
   var e = event.toElement || event.relatedTarget;
   if (elem.has(e).length > 0) return;

   // Some code here
});

简单地，我们可以检查e.relatedTarget是否有子类，如果为真则返回函数。

    if ($(e.relatedTarget).hasClass("ctrl-btn")){
        return;
    }

这是为我工作的代码，我用于html5视频播放，暂停按钮切换悬停视频元素

element.on("mouseover mouseout", function(e) {

    if(e.type === "mouseout"){

        if ($(e.relatedTarget).hasClass("child-class")){
            return;
        }

    }

});