我也遇到过类似的问题，我在这里找到了解决方案: https://stackoverflow.com/a/16909141/3934886

解决方案是一个固定的中心div和液体边列。

.center{
    background:#ddd;
    width: 500px;
    float:left;
}

.left{
    background:#999;
    width: calc(50% - 250px);
    float:left;
}

.right{
    background:#999;
    width: calc(50% - 250px);
    float:right;
}

如果你想要一个固定的左列，只需相应地改变公式。

解决方案来自display属性。

基本上你需要让两个div像表格单元一样。所以不是使用float:left，你必须在两个div上使用display:table-cell，对于动态宽度div，你需要设置width:auto;也。这两个div都应该放在一个100%宽度的容器中，并使用display:table属性。

下面是css:

.container {display:table;width:100%}
#search {
  width: 160px;
  height: 25px;
  display:table-cell;
  background-color: #FFF;
}
#navigation {
  width: auto;
  display:table-cell;
  /*background-color: url('../images/transparent.png') ;*/
  background-color: #A53030;
}

*html #navigation {float:left;}

而HTML:

<div class="container">
   <div id="search"></div>
   <div id="navigation"></div>
</div>

重要提示:对于Internet Explorer，您需要在动态宽度div上指定float属性，否则空间将不会被填充。

我希望这能解决你的问题。 如果你愿意，你可以在我的博客上阅读关于这一点的完整文章。

最简单的解决方案是让左边div的宽度等于100% -右边div的宽度加上它们之间的任何边距。

<div class="cont">
  <div class="search">
    Big Logo Text
  </div>
  <nav>
    <ul class="navbar">
      <li><a href="#1">NavLink1</a></li>
      <li><a href="#2">NavLink2</a></li>
      <li><a href="#3">NavLink3</a></li>
      <li><a href="#4">NavLink4</a></li>
      <li><a href="#5">NavLink5</a></li>
    </ul>
  </nav>
</div>

.cont{
  display: inline-grid;
  grid-template-columns: 160px 10px calc(100% - 170px);
  grid-template-rows: auto;
  grid-template-areas: "search .  navigation";
  width: 100%;
  height: auto;
  text-align: center;
}

.search {
  grid-area: search;
  height: 90px;
  background-color: #00FF00;
  line-height: 80px;
  font-size: 1.4rem;
  font-weight: 600;
}
nav {
  grid-area: navigation;
  height: 90px;
  background-color: #A53030;
}

.navbar{
  display: flex;
  height: 30px;
  width: 100%;
  padding: 0%;
  list-style-type: none;
  flex-flow: row wrap;
  flex: 0 1 auto;
  justify-content: space-between;
  align-content: flex-start;
  align-items: flex-start;
}

.navbar a{
    outline: 0;
    text-decoration: none;
}

https://codepen.io/tamjk/pen/dybqKBN

我已经在这个问题上工作了两天，有一个解决方案，可能适用于你和任何人试图使一个响应固定宽度左侧，并有右侧填补屏幕的其余部分，而不环绕左侧。我认为这样做的目的是使页面在浏览器和移动设备上都能响应。

这里是密码

// Fix the width of the right side to cover the screen when resized $thePageRefreshed = true; // The delay time below is needed to insure that the resize happens after the window resize event fires // In addition the show() helps. Without this delay the right div may go off screen when browser is refreshed setTimeout(function(){ fixRightSideWidth(); $('.right_content_container').show(600); }, 50); // Capture the window resize event (only fires when you resize the browser). $( window ).resize(function() { fixRightSideWidth(); }); function fixRightSideWidth(){ $blockWrap = 300; // Point at which you allow the right div to drop below the top div $normalRightResize = $( window ).width() - $('.left_navigator_items').width() - 20; // The -20 forces the right block to fall below the left if( ($normalRightResize >= $blockWrap) || $thePageRefreshed == true ){ $('.right_content_container').width( $normalRightResize ); $('.right_content_container').css("padding-left","0px"); /* Begin test lines these can be deleted */ $rightrightPosition = $('.right_content_container').css("right"); $rightleftPosition = $('.right_content_container').css("left"); $rightwidthPosition = $('.right_content_container').css("width"); $(".top_title").html('window width: '+$( window ).width()+"&nbsp;"+'width: '+$rightwidthPosition+"&nbsp;"+'right: '+$rightrightPosition); /* End test lines these can be deleted */ } else{ if( $('.right_content_container').width() > 300 ){ $('.right_content_container').width(300); } /* Begin test lines these can be deleted */ $rightrightPosition = $('.right_content_container').css("right"); $rightleftPosition = $('.right_content_container').css("left"); $rightwidthPosition = $('.right_content_container').css("width"); $(".top_title").html('window width: '+$( window ).width()+"&nbsp;"+'width: '+$rightwidthPosition+"&nbsp;"+'right: '+$rightrightPosition); /* End test lines these can be deleted */ } if( $thePageRefreshed == true ){ $thePageRefreshed = false; } } /* NOTE: The html and body settings are needed for full functionality and they are ignored by jsfiddle so create this exapmle on your web site */ html { min-width: 310px; background: #333; min-height:100vh; } body{ background: #333; background-color: #333; color: white; min-height:100vh; } .top_title{ background-color: blue; text-align: center; } .bottom_content{ border: 0px; height: 100%; } .left_right_container * { position: relative; margin: 0px; padding: 0px; background: #333 !important; background-color: #333 !important; display:inline-block; text-shadow: none; text-transform: none; letter-spacing: normal; font-size: 14px; font-weight: 400; font-family: -apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Oxygen-Sans,Ubuntu,Cantarell,"Helvetica Neue",sans-serif; border-radius: 0; box-sizing: content-box; transition: none; } .left_navigator_item{ display:inline-block; margin-right: 5px; margin-bottom: 0px !important; width: 100%; min-height: 20px !important; text-align:center !important; margin: 0px; padding-top: 3px; padding-bottom: 3px; vertical-align: top; } .left_navigator_items { float: left; width: 150px; } .right_content_container{ float: right; overflow: visible!important; width:95%; /* width don't matter jqoery overwrites on refresh */ display:none; right:0px; } .span_text{ background: #eee !important; background-color: #eee !important; color: black !important; padding: 5px; margin: 0px; } <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.1.1/jquery.min.js"></script> <div class="top_title">Test Title</div> <div class="bottom_content"> <div class="left_right_container"> <div class="left_navigator_items"> <div class="left_navigator_item">Dashboard</div> <div class="left_navigator_item">Calendar</div> <div class="left_navigator_item">Calendar Validator</div> <div class="left_navigator_item">Bulletin Board Slide Editor</div> <div class="left_navigator_item">Bulletin Board Slide Show (Live)</div> <div class="left_navigator_item">TV Guide</div> </div> <div class="right_content_container"> <div class="span_text">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nullam ullamcorper maximus tellus a commodo. Fusce posuere at nisi in venenatis. Sed posuere dui sapien, sit amet facilisis purus maximus sit amet. Proin luctus lectus nec rutrum accumsan. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Ut fermentum lectus consectetur sapien tempus molestie. Donec bibendum pulvinar purus, ac aliquet est commodo sit amet. Duis vel euismod mauris, eu congue ex. In vel arcu vel sem lobortis posuere. Cras in nisi nec urna blandit porta at et nunc. Morbi laoreet consectetur odio ultricies ullamcorper. Suspendisse potenti. Nulla facilisi. Quisque cursus lobortis molestie. Aliquam ut scelerisque leo. Integer sed sodales lectus, eget varius odio. Nullam nec dapibus lorem. Aenean a mattis velit, ut porta nunc. Phasellus aliquam volutpat molestie. Aliquam tristique purus neque, vitae interdum ante aliquam ut. Pellentesque quis finibus velit. Fusce ac pulvinar est, in placerat sem. Suspendisse nec nunc id nunc vestibulum hendrerit. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Mauris id lectus dapibus, tempor nunc non, bibendum nisl. Proin euismod, erat nec aliquet mollis, erat metus convallis nulla, eu tincidunt eros erat a lectus. Vivamus sed mattis neque. In vitae pellentesque mauris. Ut aliquet auctor vulputate. Duis eleifend tincidunt gravida. Sed tincidunt blandit tempor. Duis pharetra, elit id aliquam placerat, nunc arcu interdum neque, ac luctus odio felis vitae magna. Curabitur commodo finibus suscipit. Maecenas ut risus eget nisl vehicula feugiat. Sed sed bibendum justo. Curabitur in laoreet dolor. Suspendisse eget ligula ac neque ullamcorper blandit. Phasellus sit amet ultricies tellus. In fringilla, augue sed fringilla accumsan, orci eros laoreet urna, vel aliquam ex nulla in eros. Quisque aliquet nisl et scelerisque vehicula. Curabitur facilisis, nisi non maximus facilisis, augue erat gravida nunc, in tempus massa diam id dolor. Suspendisse dapibus leo vel pretium ultrices. Sed finibus dolor est, sit amet pharetra quam dapibus fermentum. Ut nec risus pharetra, convallis nisl nec, tempor nisl. Vivamus sit amet quam quis dolor dapibus maximus. Suspendisse accumsan sagittis ligula, ut ultricies nisi feugiat pretium. Cras aliquam velit eu venenatis accumsan. Integer imperdiet, eros sit amet dignissim volutpat, tortor enim varius turpis, vel viverra ante mauris at felis. Mauris sed accumsan sapien. Interdum et malesuada fames ac ante ipsum primis in faucibus. Ut vel magna commodo, facilisis turpis eu, semper mi. Nulla massa risus, bibendum a magna molestie, gravida maximus nunc.</div> </div> </div> </div>

这是我的小提琴，它可能对你有用，就像对我一样。 https://jsfiddle.net/Larry_Robertson/62LLjapm/

@Boushley的回答是最接近的，但是有一个问题没有解决，但已经指出了。右边的div取浏览器的整个宽度;内容采用预期的宽度。为了更好地看待这个问题:

<html>
<head>
    <style type="text/css">
    * { margin: 0; padding: 0; }
    body {
        height: 100%;
    }
    #left {
        opacity: 0;
        height: inherit;
        float: left;
        width: 180px;
        background: green;
    }
    #right {
        height: inherit;
        background: orange;
    }
    table {
            width: 100%;
            background: red;
    }
    </style>
</head>
<body>
    <div id="left">
        <p>Left</p>
    </div>
    <div id="right">
        <table><tr><td>Hello, World!</td></tr></table>
    </div>
</body>
</html>

http://jsfiddle.net/79hpS/

内容在正确的位置(在Firefox中)，但是宽度不正确。当子元素开始继承width时(例如，width: 100%的表)，它们被赋予的宽度等于浏览器的宽度，导致它们溢出页面的右侧并创建一个水平滚动条(在Firefox中)或不浮动并向下推(在chrome中)。

您可以通过向右列添加overflow: hidden来轻松解决这个问题。这将为内容和div提供正确的宽度。此外，表格将接收正确的宽度，并填充可用的剩余宽度。

我尝试了上面的一些其他解决方案，它们在某些边缘情况下并不完全有效，而且太复杂了，无法进行修复。这很有效，也很简单。

如果有任何问题或顾虑，请尽管提出来。

如果您试图填充flexbox中2项之间的剩余空间，请将以下类添加到您想要分离的2项之间的空div:

.fill {
  // This fills the remaining space, by using flexbox. 
  flex: 1 1 auto;
}