最简单的解决方案是让左边div的宽度等于100% -右边div的宽度加上它们之间的任何边距。

<div class="cont">
  <div class="search">
    Big Logo Text
  </div>
  <nav>
    <ul class="navbar">
      <li><a href="#1">NavLink1</a></li>
      <li><a href="#2">NavLink2</a></li>
      <li><a href="#3">NavLink3</a></li>
      <li><a href="#4">NavLink4</a></li>
      <li><a href="#5">NavLink5</a></li>
    </ul>
  </nav>
</div>

.cont{
  display: inline-grid;
  grid-template-columns: 160px 10px calc(100% - 170px);
  grid-template-rows: auto;
  grid-template-areas: "search .  navigation";
  width: 100%;
  height: auto;
  text-align: center;
}

.search {
  grid-area: search;
  height: 90px;
  background-color: #00FF00;
  line-height: 80px;
  font-size: 1.4rem;
  font-weight: 600;
}
nav {
  grid-area: navigation;
  height: 90px;
  background-color: #A53030;
}

.navbar{
  display: flex;
  height: 30px;
  width: 100%;
  padding: 0%;
  list-style-type: none;
  flex-flow: row wrap;
  flex: 0 1 auto;
  justify-content: space-between;
  align-content: flex-start;
  align-items: flex-start;
}

.navbar a{
    outline: 0;
    text-decoration: none;
}

https://codepen.io/tamjk/pen/dybqKBN

如果有人需要相同的解决方案，但没有固定长度的左div:

如果你想让左边的div占据所有的空间，你可以删除固定大小的180px。参见下面的CSS:

#left {
  float: left;
  background-color: red;
}

#right {
  background-color: yellow;
  flex-grow: 1
}

参见这里的JSFiddle: JSFiddle -div-space

由于这是一个相当流行的问题，我倾向于分享一个使用BFC的很好的解决方案。 代码样例如下。

.left {
  float: left;
  width: 100px;
}
.right {
  overflow: auto;
}

在这种情况下，overflow: auto触发上下文行为，并使右元素仅扩展到可用的剩余宽度，如果.left消失，它将自然扩展到全宽度。对于许多UI布局来说，这是一个非常有用和干净的技巧，但一开始可能很难理解“为什么它有效”。

使用显示:flex

<div style="width:500px; display:flex">
   <div style="width:150px; height:30px; background:red">fixed width</div>

   <div style="width:100%; height:30px; background:green">remaining</div>
</div>

尝试添加相对位置，删除右边的宽度和浮动属性，然后添加0值的左和右属性。

此外，您还可以添加左距规则，其值基于左元素的宽度(如果您需要在两者之间留出空间，则要加上一些像素)来保持其位置。

这个例子对我来说很有用:

   #search {
        width: 160px;
        height: 25px;
        float: left;
        background-color: #FFF;
    }

    #navigation {  
        display: block;  
        position: relative;
        left: 0;
        right: 0;
        margin: 0 0 0 166px;             
        background-color: #A53030;
    }

我已经在这个问题上工作了两天，有一个解决方案，可能适用于你和任何人试图使一个响应固定宽度左侧，并有右侧填补屏幕的其余部分，而不环绕左侧。我认为这样做的目的是使页面在浏览器和移动设备上都能响应。

这里是密码

// Fix the width of the right side to cover the screen when resized $thePageRefreshed = true; // The delay time below is needed to insure that the resize happens after the window resize event fires // In addition the show() helps. Without this delay the right div may go off screen when browser is refreshed setTimeout(function(){ fixRightSideWidth(); $('.right_content_container').show(600); }, 50); // Capture the window resize event (only fires when you resize the browser). $( window ).resize(function() { fixRightSideWidth(); }); function fixRightSideWidth(){ $blockWrap = 300; // Point at which you allow the right div to drop below the top div $normalRightResize = $( window ).width() - $('.left_navigator_items').width() - 20; // The -20 forces the right block to fall below the left if( ($normalRightResize >= $blockWrap) || $thePageRefreshed == true ){ $('.right_content_container').width( $normalRightResize ); $('.right_content_container').css("padding-left","0px"); /* Begin test lines these can be deleted */ $rightrightPosition = $('.right_content_container').css("right"); $rightleftPosition = $('.right_content_container').css("left"); $rightwidthPosition = $('.right_content_container').css("width"); $(".top_title").html('window width: '+$( window ).width()+"&nbsp;"+'width: '+$rightwidthPosition+"&nbsp;"+'right: '+$rightrightPosition); /* End test lines these can be deleted */ } else{ if( $('.right_content_container').width() > 300 ){ $('.right_content_container').width(300); } /* Begin test lines these can be deleted */ $rightrightPosition = $('.right_content_container').css("right"); $rightleftPosition = $('.right_content_container').css("left"); $rightwidthPosition = $('.right_content_container').css("width"); $(".top_title").html('window width: '+$( window ).width()+"&nbsp;"+'width: '+$rightwidthPosition+"&nbsp;"+'right: '+$rightrightPosition); /* End test lines these can be deleted */ } if( $thePageRefreshed == true ){ $thePageRefreshed = false; } } /* NOTE: The html and body settings are needed for full functionality and they are ignored by jsfiddle so create this exapmle on your web site */ html { min-width: 310px; background: #333; min-height:100vh; } body{ background: #333; background-color: #333; color: white; min-height:100vh; } .top_title{ background-color: blue; text-align: center; } .bottom_content{ border: 0px; height: 100%; } .left_right_container * { position: relative; margin: 0px; padding: 0px; background: #333 !important; background-color: #333 !important; display:inline-block; text-shadow: none; text-transform: none; letter-spacing: normal; font-size: 14px; font-weight: 400; font-family: -apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Oxygen-Sans,Ubuntu,Cantarell,"Helvetica Neue",sans-serif; border-radius: 0; box-sizing: content-box; transition: none; } .left_navigator_item{ display:inline-block; margin-right: 5px; margin-bottom: 0px !important; width: 100%; min-height: 20px !important; text-align:center !important; margin: 0px; padding-top: 3px; padding-bottom: 3px; vertical-align: top; } .left_navigator_items { float: left; width: 150px; } .right_content_container{ float: right; overflow: visible!important; width:95%; /* width don't matter jqoery overwrites on refresh */ display:none; right:0px; } .span_text{ background: #eee !important; background-color: #eee !important; color: black !important; padding: 5px; margin: 0px; } <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.1.1/jquery.min.js"></script> <div class="top_title">Test Title</div> <div class="bottom_content"> <div class="left_right_container"> <div class="left_navigator_items"> <div class="left_navigator_item">Dashboard</div> <div class="left_navigator_item">Calendar</div> <div class="left_navigator_item">Calendar Validator</div> <div class="left_navigator_item">Bulletin Board Slide Editor</div> <div class="left_navigator_item">Bulletin Board Slide Show (Live)</div> <div class="left_navigator_item">TV Guide</div> </div> <div class="right_content_container"> <div class="span_text">Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nullam ullamcorper maximus tellus a commodo. Fusce posuere at nisi in venenatis. Sed posuere dui sapien, sit amet facilisis purus maximus sit amet. Proin luctus lectus nec rutrum accumsan. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Ut fermentum lectus consectetur sapien tempus molestie. Donec bibendum pulvinar purus, ac aliquet est commodo sit amet. Duis vel euismod mauris, eu congue ex. In vel arcu vel sem lobortis posuere. Cras in nisi nec urna blandit porta at et nunc. Morbi laoreet consectetur odio ultricies ullamcorper. Suspendisse potenti. Nulla facilisi. Quisque cursus lobortis molestie. Aliquam ut scelerisque leo. Integer sed sodales lectus, eget varius odio. Nullam nec dapibus lorem. Aenean a mattis velit, ut porta nunc. Phasellus aliquam volutpat molestie. Aliquam tristique purus neque, vitae interdum ante aliquam ut. Pellentesque quis finibus velit. Fusce ac pulvinar est, in placerat sem. Suspendisse nec nunc id nunc vestibulum hendrerit. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Mauris id lectus dapibus, tempor nunc non, bibendum nisl. Proin euismod, erat nec aliquet mollis, erat metus convallis nulla, eu tincidunt eros erat a lectus. Vivamus sed mattis neque. In vitae pellentesque mauris. Ut aliquet auctor vulputate. Duis eleifend tincidunt gravida. Sed tincidunt blandit tempor. Duis pharetra, elit id aliquam placerat, nunc arcu interdum neque, ac luctus odio felis vitae magna. Curabitur commodo finibus suscipit. Maecenas ut risus eget nisl vehicula feugiat. Sed sed bibendum justo. Curabitur in laoreet dolor. Suspendisse eget ligula ac neque ullamcorper blandit. Phasellus sit amet ultricies tellus. In fringilla, augue sed fringilla accumsan, orci eros laoreet urna, vel aliquam ex nulla in eros. Quisque aliquet nisl et scelerisque vehicula. Curabitur facilisis, nisi non maximus facilisis, augue erat gravida nunc, in tempus massa diam id dolor. Suspendisse dapibus leo vel pretium ultrices. Sed finibus dolor est, sit amet pharetra quam dapibus fermentum. Ut nec risus pharetra, convallis nisl nec, tempor nisl. Vivamus sit amet quam quis dolor dapibus maximus. Suspendisse accumsan sagittis ligula, ut ultricies nisi feugiat pretium. Cras aliquam velit eu venenatis accumsan. Integer imperdiet, eros sit amet dignissim volutpat, tortor enim varius turpis, vel viverra ante mauris at felis. Mauris sed accumsan sapien. Interdum et malesuada fames ac ante ipsum primis in faucibus. Ut vel magna commodo, facilisis turpis eu, semper mi. Nulla massa risus, bibendum a magna molestie, gravida maximus nunc.</div> </div> </div> </div>

这是我的小提琴，它可能对你有用，就像对我一样。 https://jsfiddle.net/Larry_Robertson/62LLjapm/