我个人认为，以下是用Python编写原始SQL查询的最佳（简单、安全和Python化）方法，尤其是在使用Python的sqlite3模块时：

query = '''
    SELECT
        action.descr as action,
        role.id as role_id,
        role.descr as role
    FROM
        public.role_action_def,
        public.role,
        public.record_def,
        public.action
    WHERE
        role.id = role_action_def.role_id
        AND record_def.id = role_action_def.def_id
        AND action.id = role_action_def.action_id
        AND role_action_def.account_id = ?
        AND record_def.account_id = ?
        AND def_id = ?
'''
vars = (account_id, account_id, def_id)   # a tuple of query variables
cursor.execute(query, vars)   # using Python's sqlite3 module

Pros

整洁而简单的代码（Pythonic！）避免SQL注入与Python 2和Python 3兼容（毕竟是Pythonic）不需要字符串串联无需确保每行最右边的字符是空格

Cons

由于查询中的变量被替换为？占位符，它可能会变得有点难以跟踪哪个？当查询中有很多Python变量时，将由哪个Python变量替换。

我认为当代码（例如，变量）缩进并且输出字符串应该是单行（没有换行）时，另一个选项更可读：

def some_method():

    long_string = """
A presumptuous long string
which looks a bit nicer
in a text editor when
written over multiple lines
""".strip('\n').replace('\n', ' ')

    return long_string

为了在字典内定义长字符串，保留换行符但省略空格，我最终以如下常量定义字符串：

LONG_STRING = \
"""
This is a long sting
that contains newlines.
The newlines are important.
"""

my_dict = {
   'foo': 'bar',
   'string': LONG_STRING
}

我发现，当构建长字符串时，您通常会做一些类似于构建SQL查询的事情，在这种情况下，这是最好的：

query = ' '.join((  # Note double parentheses. join() takes an iterable
    "SELECT foo",
    "FROM bar",
    "WHERE baz",
))

Levon的建议很好，但可能容易出错：

query = (
    "SELECT foo"
    "FROM bar"
    "WHERE baz"
)

query == "SELECT fooFROM barWHERE baz"  # Probably not what you want

“la”Scala方式（但我认为这是OP要求的最具Python风格的方式）：

description = """
            | The intention of this module is to provide a method to
            | pass meta information in markdown_ header files for
            | using it in jinja_ templates.
            |
            | Also, to provide a method to use markdown files as jinja
            | templates. Maybe you prefer to see the code than
            | to install it.""".replace('\n            | \n','\n').replace('            | ',' ')

如果您希望最后的str没有跳转行，只需将\n放在第二个替换的第一个参数的开头：

.replace('\n            | ',' ')`.

注意：“…templates.”和“另外，…”之间的白线需要在|后面加一个空格。

添加@Levon的答案。。。。

1.创建如下多行字符串：

paragraph = """this is a very
        long string if I had the
        energy to type more and more ..."""

print(paragraph)

输出：

'this is a very\n        long string if I had the\n        energy to type more and more ...'

此字符串将包含换行符和空格。因此，请移除它们。

2.使用正则表达式删除多余的空格

paragraph = re.sub('\s+', ' ', paragraph)
print(paragraph)

输出：

'this is a very long string if I had the energy to type more and more ...'