在Windows 7、Visual Studio Express 2010下，如果已激活选项“为Windows XP SP3使用兼容性模式”，则可能会出现此错误。

我取消了这个选项，它再次完美地工作了。右键单击VS或可执行文件的快捷方式，选择属性，然后选择兼容性。

你做过这种事吗?

是否继续运行最后一个成功的构建?

如果您勾选了方框并按下“是”，即使您的项目没有编译，您也将成功运行最后一个构建。这意味着无论何时设置断点，都将得到该错误。

试着改变这个值:

工具 选项 项目和解决方案 构建并运行 在运行时，发生构建或部署错误时:不启动

我刚刚重启电脑，它为我工作得很好。

因为构建版本更改了(很可能您修改了源代码)，所以重新编译解决方案并再次运行应用程序，之后它将到达调试断点。

我只是重新装填，清理和重建我的作品。

This happen often also if you are using a file references to binaries (instead of project references to code in your project), and the compiled binary that you are referencing falls out of sync with the corresponding source code on your machine. This can happen because you downloaded a new version of the binary from source control without the new source code that went with it, or you have a few versions of the binary on your machine and are referencing an old copy, etc. If this is indeed the problem, it's a good reason to use project references as much as it practical.