如果你想要填充你的超级视图，那么我建议快速的方法:

view.translatesAutoresizingMaskIntoConstraints = false
let attributes: [NSLayoutAttribute] = [.top, .bottom, .right, .left]
NSLayoutConstraint.activate(attributes.map {
    NSLayoutConstraint(item: view, attribute: $0, relatedBy: .equal, toItem: view.superview, attribute: $0, multiplier: 1, constant: 0)
})

否则，如果你需要非相等的约束检查NSLayoutAnchor作为iOS 9。使用NSLayoutConstraint直接读取通常要容易得多:

view.translatesAutoresizingMaskIntoConstraints = false
view.topAnchor.constraint(equalTo: view.superview!.topAnchor).isActive = true
view.bottomAnchor.constraint(equalTo: view.superview!.bottomAnchor).isActive = true
view.leadingAnchor.constraint(equalTo: view.superview!.leadingAnchor, constant: 10).isActive = true
view.trailingAnchor.constraint(equalTo: view.superview!.trailingAnchor, constant: 10).isActive = true

您正在向self添加所有已定义的约束。视图的宽度和高度限制应该添加到你的newView。

另外，据我所知，你想要设置恒定的宽度和高度100:100。 在这种情况下，您应该将代码更改为:

var constW = NSLayoutConstraint(item: newView, 
    attribute: .Width, 
    relatedBy: .Equal, 
    toItem: nil, 
    attribute: .NotAnAttribute, 
    multiplier: 1, 
    constant: 100)
newView.addConstraint(constW)

var constH = NSLayoutConstraint(item: newView, 
    attribute: .Height, 
    relatedBy: .Equal, 
    toItem: nil, 
    attribute: .NotAnAttribute, 
    multiplier: 1, 
    constant: 100)
newView.addConstraint(constH)

    var xCenterConstraint : NSLayoutConstraint!
    var yCenterConstraint: NSLayoutConstraint!

 xCenterConstraint = NSLayoutConstraint(item: self.view, attribute: .CenterX, relatedBy: .Equal, toItem: (Your view NAme), attribute: .CenterX, multiplier: 1, constant: 0)
            self.view.addConstraint(xCenterConstraint)

 yCenterConstraint = NSLayoutConstraint(item: self.view, attribute: .CenterY, relatedBy: .Equal, toItem: (Your view Name), attribute: .CenterY, multiplier: 1, constant: 0)
            self.view.addConstraint(yCenterConstraint)

这是一种以编程方式添加约束的方法

override func viewDidLoad() {
            super.viewDidLoad()


let myLabel = UILabel()
        myLabel.labelFrameUpdate(label: myLabel, text: "Welcome User", font: UIFont(name: "times new roman", size: 40)!, textColor: UIColor.red, textAlignment: .center, numberOfLines: 0, borderWidth: 2.0, BorderColor: UIColor.red.cgColor)
        self.view.addSubview(myLabel)


         let myLabelhorizontalConstraint = NSLayoutConstraint(item: myLabel, attribute: NSLayoutAttribute.centerX, relatedBy: NSLayoutRelation.equal, toItem: self.view, attribute: NSLayoutAttribute.centerX, multiplier: 1, constant: 0)
        let myLabelverticalConstraint = NSLayoutConstraint(item: myLabel, attribute: NSLayoutAttribute.centerY, relatedBy: NSLayoutRelation.equal, toItem: self.view, attribute: NSLayoutAttribute.centerY, multiplier: 1, constant: 0)
        let mylabelLeading = NSLayoutConstraint(item: myLabel, attribute: NSLayoutAttribute.leading, relatedBy: NSLayoutRelation.equal, toItem: self.view, attribute: NSLayoutAttribute.leading, multiplier: 1, constant: 10)
        let mylabelTrailing = NSLayoutConstraint(item: myLabel, attribute: NSLayoutAttribute.trailing, relatedBy: NSLayoutRelation.equal, toItem: self.view, attribute: NSLayoutAttribute.trailing, multiplier: 1, constant: -10)
        let myLabelheightConstraint = NSLayoutConstraint(item: myLabel, attribute: NSLayoutAttribute.height, relatedBy: NSLayoutRelation.equal, toItem: nil, attribute: NSLayoutAttribute.notAnAttribute, multiplier: 1, constant: 50)
        NSLayoutConstraint.activate(\[myLabelhorizontalConstraint, myLabelverticalConstraint, myLabelheightConstraint,mylabelLeading,mylabelTrailing\])
}

extension UILabel
{
    func labelFrameUpdate(label:UILabel,text:String = "This is sample Label",font:UIFont = UIFont(name: "times new roman", size: 20)!,textColor:UIColor = UIColor.red,textAlignment:NSTextAlignment = .center,numberOfLines:Int = 0,borderWidth:CGFloat = 2.0,BorderColor:CGColor = UIColor.red.cgColor){
        label.translatesAutoresizingMaskIntoConstraints = false
        label.text = text
        label.font = font
        label.textColor = textColor
        label.textAlignment = textAlignment
        label.numberOfLines = numberOfLines
        label.layer.borderWidth = borderWidth
        label.layer.borderColor = UIColor.red.cgColor
    }
}

您可以使用Snapkit以编程方式设置约束。

class ViewController: UIViewController {
    
    let rectView: UIView = UIView(frame: CGRect(x: 0, y: 0, width: 100, height: 100))
    
    override func viewDidLoad() {
        super.viewDidLoad()
        setupViews()
    }
    
    private func setupViews() {
        rectView.backgroundColor = .red
        view.addSubview(rectView)

        rectView.snp.makeConstraints {
          $0.center.equalToSuperview()
        }
    }
}

基本上有3个步骤

fileprivate func setupName() { 

    lblName.text = "Hello world"

    // Step 1
    lblName.translatesAutoresizingMaskIntoConstraints = false

    //Step 2
    self.view.addSubview(lblName)

    //Step 3
    NSLayoutConstraint.activate([
        lblName.centerXAnchor.constraint(equalTo: self.view.centerXAnchor),
        lblName.centerYAnchor.constraint(equalTo: self.view.centerYAnchor)
    ])
}

这将把标签“hello world”置于屏幕中心。

请参考链接自动布局约束编程