在Xcode 6中，你可以在storyboard中这样做:

SWIFT 3有用的扩展设置行间的空间更容易:)

extension UILabel
{
    func setLineHeight(lineHeight: CGFloat)
    {
        let text = self.text
        if let text = text 
        {

            let attributeString = NSMutableAttributedString(string: text)
            let style = NSMutableParagraphStyle()

           style.lineSpacing = lineHeight
           attributeString.addAttribute(NSParagraphStyleAttributeName,
                                        value: style,
                                        range: NSMakeRange(0, text.characters.count))

           self.attributedText = attributeString
        }
    }
}

这里提到的解决方案对我不起作用。我发现了一个稍微不同的方式来做它与iOS 6 NSAttributeString:

myLabel.numberOfLines = 0; 
NSString* string = @"String with line one. \n Line two. \n Line three.";
NSMutableParagraphStyle *style  = [[NSMutableParagraphStyle alloc] init];
style.minimumLineHeight = 30.f;
style.maximumLineHeight = 30.f;
NSDictionary *attributtes = @{NSParagraphStyleAttributeName : style,};
myLabel.attributedText = [[NSAttributedString alloc] initWithString:string
                                                         attributes:attributtes];   
[myLabel sizeToFit];

这应该会有帮助。然后你可以将你的标签分配给故事板中的这个自定义类，并直接在属性中使用它的参数:

open class SpacingLabel : UILabel {

    @IBInspectable open var lineHeight:CGFloat = 1 {
        didSet {
            let paragraphStyle = NSMutableParagraphStyle()
            paragraphStyle.lineSpacing = 1.0
            paragraphStyle.lineHeightMultiple = self.lineHeight
            paragraphStyle.alignment = self.textAlignment

            let attrString = NSMutableAttributedString(string: self.text!)
            attrString.addAttribute(NSAttributedStringKey.font, value: self.font, range: NSMakeRange(0, attrString.length))
            attrString.addAttribute(NSAttributedStringKey.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))
            self.attributedText = attrString
        }
    } 
}

Swift 3扩展:

import UIKit
    
extension UILabel {
  func setTextWithLineSpacing(text: String, lineHeightMultiply: CGFloat = 1.3) {
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineHeightMultiple = lineHeightMultiply
    paragraphStyle.alignment = .center
    let attributedString = NSMutableAttributedString(string: text)
    attributedString.addAttribute(NSParagraphStyleAttributeName, value: paragraphStyle, range: NSRange(location: 0, length: attributedString.length))
    self.attributedText = attributedString
  }
}

我想在这个答案中加入一些新的东西，这样我就不会感觉那么糟糕了……以下是斯威夫特的回答:

import Cocoa

let paragraphStyle = NSMutableParagraphStyle()
paragraphStyle.lineSpacing = 40

let attrString = NSMutableAttributedString(string: "Swift Answer")
attrString.addAttribute(.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

var tableViewCell = NSTableCellView()
tableViewCell.textField.attributedStringValue = attrString

简单的回答是:你不能。要改变文本行间的间距，你必须继承UILabel并滚动自己的drawTextInRect，或者创建多个标签。”

参见:设置UILabel行间距

这是一个非常老的答案，其他人已经添加了新的更好的方法来处理这个问题。请参阅下面提供的最新答案。