您的程序集是否正确签名?

要检查这一点，在项目上按Alt+Enter(或右键单击，然后Properties)。点击“签名”。验证复选框“签名程序集”已选中，强名称密钥文件已选中，且“仅延迟签名”未选中。

为任何人添加我的解决方案，这可能会有所帮助。

I had a ClickOnce solution throwing this error. The app referenced a common "Libs" folder and contained a project reference to a Foo.dll. While none of the projects in the solution referenced the static copy of the Foo.dll in the "Libs" folder, some of the references in that folder did (ie: my solution had refs to Libs\Bar.dll which referenced Foo.dll.) Since the CO app pulled all the dependencies from Libs as well as their dependencies, both copies were going into the project. This was generating the error above.

我通过将我的Libs\Foo.dll静态版本移动到一个子文件夹Libs\Fix\Foo.dll来解决这个问题。此更改使ClickOnce应用程序只使用DLL的项目版本，并且错误消失了。

卸载和重新加载项目的问题解决了它为我。

我在从包中迁移Excel插件后遇到了这个问题。配置到PackageReference。似乎和这个问题有关。

如果你不使用ClickOnce，下面的工作作为一个粗略的解决方案(它将从.manifest文件中省略所有依赖信息):

Unload project, edit .csproj Find the section looking like this: <!-- Include additional build rules for an Office application add-in. --> <Import Project="$(VSToolsPath)\OfficeTools\Microsoft.VisualStudio.Tools.Office.targets" Condition="'$(VSToolsPath)' != ''" /> Edit a renamed copy of the referenced .targets file (in my case, the file resolved to C:\Program Files (x86)\Microsoft Visual Studio\2017\Professional\MSBuild\Microsoft\VisualStudio\v15.0\OfficeTools\Microsoft.VisualStudio.Tools.Office.targets and I made a copy Microsoft.VisualStudio.Tools.Office_FIX.targets in the same folder - didn't check if it works from a different folder). Find the GenerateApplicationManifest element and change its attribute Dependencies="@(DependenciesForGam)" to Dependencies="". Change the section found in 2. to reference your edited .targets file instead.

每当VS附带的.targets文件版本更新(或者你不会得到更新)时，这将不得不重复，但我希望它能很快得到修复…

您需要使用密钥对程序集进行签名。进入选项卡签名下的项目属性:

我去发布应用程序文件，发现dll抛出错误，将其从“包括(自动)”更改为“包括”。我现在可以发表了。