如果您有文件对象，那么

>>> import os
>>> with open('new_file.txt') as my_file:
...     my_file.seek(0, os.SEEK_END) # go to end of file
...     if my_file.tell(): # if current position is truish (i.e != 0)
...         my_file.seek(0) # rewind the file for later use 
...     else:
...         print "file is empty"
... 
file is empty

import os    
os.path.getsize(fullpathhere) > 0

如果文件不存在，getsize()和stat()都会抛出异常。这个函数将返回True/False而不抛出(更简单但不那么健壮):

import os
def is_non_zero_file(fpath):  
    return os.path.isfile(fpath) and os.path.getsize(fpath) > 0

如果您有文件对象，那么

>>> import os
>>> with open('new_file.txt') as my_file:
...     my_file.seek(0, os.SEEK_END) # go to end of file
...     if my_file.tell(): # if current position is truish (i.e != 0)
...         my_file.seek(0) # rewind the file for later use 
...     else:
...         print "file is empty"
... 
file is empty

如果你正在使用Python 3的pathlib，你可以使用Path.stat()方法访问os.stat()信息，该方法具有st_size属性(以字节为单位的文件大小):

>>> from pathlib import Path
>>> mypath = Path("path/to/my/file")
>>> mypath.stat().st_size == 0 # True if empty

>>> import os
>>> os.stat("file").st_size == 0
True