如果出于某种原因，你已经打开了文件，你可以尝试这样做:

>>> with open('New Text Document.txt') as my_file:
...     # I already have file open at this point.. now what?
...     my_file.seek(0) # Ensure you're at the start of the file..
...     first_char = my_file.read(1) # Get the first character
...     if not first_char:
...         print "file is empty" # The first character is the empty string..
...     else:
...         my_file.seek(0) # The first character wasn't empty. Return to the start of the file.
...         # Use file now
...
file is empty

import os    
os.path.getsize(fullpathhere) > 0

>>> import os
>>> os.stat("file").st_size == 0
True

如果要检查CSV文件是否为空或 不，试试这个:

with open('file.csv', 'a', newline='') as f:
    csv_writer = DictWriter(f, fieldnames = ['user_name', 'user_age', 'user_email', 'user_gender', 'user_type', 'user_check'])
    if os.stat('file.csv').st_size > 0:
        pass
    else:
        csv_writer.writeheader()

结合ghostdog74的回答和评论:

>>> import os
>>> os.stat('c:/pagefile.sys').st_size==0
False

False表示非空文件。

让我们写一个函数:

import os

def file_is_empty(path):
    return os.stat(path).st_size==0

如果文件不存在，getsize()和stat()都会抛出异常。这个函数将返回True/False而不抛出(更简单但不那么健壮):

import os
def is_non_zero_file(fpath):  
    return os.path.isfile(fpath) and os.path.getsize(fpath) > 0