如果你不想强迫你的用户安装pip，你可以模仿它的行为:

import sys

from os import path as p

try:
    from setuptools import setup, find_packages
except ImportError:
    from distutils.core import setup, find_packages


def read(filename, parent=None):
    parent = (parent or __file__)

    try:
        with open(p.join(p.dirname(parent), filename)) as f:
            return f.read()
    except IOError:
        return ''


def parse_requirements(filename, parent=None):
    parent = (parent or __file__)
    filepath = p.join(p.dirname(parent), filename)
    content = read(filename, parent)

    for line_number, line in enumerate(content.splitlines(), 1):
        candidate = line.strip()

        if candidate.startswith('-r'):
            for item in parse_requirements(candidate[2:].strip(), filepath):
                yield item
        else:
            yield candidate

setup(
...
    install_requires=list(parse_requirements('requirements.txt'))
)

下面是一个完整的hack(用pip 9.0.1测试)，基于Romain的回答，解析requirements.txt，并根据当前的环境标记进行过滤:

from pip.req import parse_requirements

requirements = []
for r in parse_requirements('requirements.txt', session='hack'):
    # check markers, such as
    #
    #     rope_py3k    ; python_version >= '3.0'
    #
    if r.match_markers():
        requirements.append(str(r.req))

print(requirements)

它不能接受文件句柄。install_requires参数只能是字符串或字符串列表。

当然，您可以在设置脚本中读取您的文件，并将其作为字符串列表传递给install_requires。

import os
from setuptools import setup

with open('requirements.txt') as f:
    required = f.read().splitlines()

setup(...
install_requires=required,
...)

交叉张贴我从这个SO问题的答案，另一个简单的，pip版本证明解决方案。

try:  # for pip >= 10
    from pip._internal.req import parse_requirements
    from pip._internal.download import PipSession
except ImportError:  # for pip <= 9.0.3
    from pip.req import parse_requirements
    from pip.download import PipSession

requirements = parse_requirements(os.path.join(os.path.dirname(__file__), 'requirements.txt'), session=PipSession())

if __name__ == '__main__':
    setup(
        ...
        install_requires=[str(requirement.req) for requirement in requirements],
        ...
    )

然后把所有的需求放在项目根目录下的requirements.txt下。

另一个可能的解决方案……

def gather_requirements(top_path=None):
    """Captures requirements from repo.

    Expected file format is: requirements[-_]<optional-extras>.txt

    For example:

        pip install -e .[foo]

    Would require:

        requirements-foo.txt

        or

        requirements_foo.txt

    """
    from pip.download import PipSession
    from pip.req import parse_requirements
    import re

    session = PipSession()
    top_path = top_path or os.path.realpath(os.getcwd())
    extras = {}
    for filepath in tree(top_path):
        filename = os.path.basename(filepath)
        basename, ext = os.path.splitext(filename)
        if ext == '.txt' and basename.startswith('requirements'):
            if filename == 'requirements.txt':
                extra_name = 'requirements'
            else:
                _, extra_name = re.split(r'[-_]', basename, 1)
            if extra_name:
                reqs = [str(ir.req) for ir in parse_requirements(filepath, session=session)]
                extras.setdefault(extra_name, []).extend(reqs)
    all_reqs = set()
    for key, values in extras.items():
        all_reqs.update(values)
    extras['all'] = list(all_reqs)
    return extras

然后使用…

reqs = gather_requirements()
install_reqs = reqs.pop('requirements', [])
test_reqs = reqs.pop('test', [])
...
setup(
    ...
    'install_requires': install_reqs,
    'test_requires': test_reqs,
    'extras_require': reqs,
    ...
)

虽然这不是问题的确切答案，但我推荐Donald Stufft在https://caremad.io/2013/07/setup-vs-requirement/上的博客文章，它很好地回答了这个问题。我用它取得了巨大的成功。

简而言之，requirements.txt不是setup.py的替代品，而是部署的补充。在setup.py中保持包依赖关系的适当抽象。设置requirements.txt或更多的文件，以获取用于开发、测试或生产的软件包依赖关系的特定版本。

例如，在deps/下的回购中包含包:

# fetch specific dependencies
--no-index
--find-links deps/

# install package
# NOTE: -e . for editable mode
.

PIP执行包的setup.py并安装在install_requires中声明的依赖项的特定版本。没有表里不一，这两件文物的用途都被保留了下来。