我有问题与接受的答案，所以我更新了它，这是为我工作:

.h

@interface MaxSpacingCollectionViewFlowLayout : UICollectionViewFlowLayout
@property (nonatomic,assign) CGFloat maxCellSpacing;
@end

.m

@implementation MaxSpacingCollectionViewFlowLayout

- (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect {
    NSArray *attributes = [super layoutAttributesForElementsInRect:rect];

    if (attributes.count <= 0) return attributes;

    CGFloat firstCellOriginX = ((UICollectionViewLayoutAttributes *)attributes[0]).frame.origin.x;

    for(int i = 1; i < attributes.count; i++) {
        UICollectionViewLayoutAttributes *currentLayoutAttributes = attributes[i];
        if (currentLayoutAttributes.frame.origin.x == firstCellOriginX) { // The first cell of a new row
            continue;
        }

        UICollectionViewLayoutAttributes *prevLayoutAttributes = attributes[i - 1];
        CGFloat prevOriginMaxX = CGRectGetMaxX(prevLayoutAttributes.frame);
        if ((currentLayoutAttributes.frame.origin.x - prevOriginMaxX) > self.maxCellSpacing) {
            CGRect frame = currentLayoutAttributes.frame;
            frame.origin.x = prevOriginMaxX + self.maxCellSpacing;
            currentLayoutAttributes.frame = frame;
        }
    }
    return attributes;
}

@end

我在Swift 3单元格间距的解决方案，如Instagram:

lazy var collectionView: UICollectionView = {
    let layout = UICollectionViewFlowLayout()
    let cv = UICollectionView(frame: .zero, collectionViewLayout: layout)
    cv.backgroundColor = UIColor.rgb(red: 227, green: 227, blue: 227)
    cv.showsVerticalScrollIndicator = false
    layout.scrollDirection = .vertical
    layout.minimumLineSpacing = 1
    layout.minimumInteritemSpacing = 1
    return cv
}()

func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, sizeForItemAt indexPath: IndexPath) -> CGSize {

    switch UIDevice.current.modelName {
    case "iPhone 4":
        return CGSize(width: 106, height: 106)
    case "iPhone 5":
        return CGSize(width: 106, height: 106)
    case "iPhone 6,7":
        return CGSize(width: 124, height: 124)
    case "iPhone Plus":
        return CGSize(width: 137, height: 137)
    default:
        return CGSize(width: frame.width / 3, height: frame.width / 3)
    }
}

如何编程检测设备: https://stackoverflow.com/a/26962452/6013170

记住，它是最小行间距，而不是最小项间距或单元格间距。因为你的collectionView的滚动方向是水平的。

如果是垂直的，则需要为单元格之间的水平空间设置单元格空间或项间空间，为单元格之间的垂直空间设置行间距。

objective - c版本

- (CGFloat)collectionView:(UICollectionView *)collectionView
                       layout:(UICollectionViewLayout*)collectionViewLayout
    minimumLineSpacingForSectionAtIndex:(NSInteger)section
    {
        return 20;
    }

斯威夫特版本:

func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumLineSpacingForSectionAt section: Int) -> CGFloat {
    return 20
}

如果你想在不影响实际单元格大小的情况下调整间距，这是最适合我的解决方案。#xcode 9 #tvOS11 #iOS11 #swift

在uicollectionviewdelegatflowlayout中，改变实现下一个方法，诀窍是你必须使用它们两个，文档并没有真正指向我去思考那个方向。: D

open func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumInteritemSpacingForSectionAt section: Int) -> CGFloat {
    return cellSpacing
}

public func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumLineSpacingForSectionAt section: Int) -> CGFloat {
    return cellSpacing
}

Swift 5 UIKit编程

 //Create UICollectionView
lazy var collectionView: UICollectionView = {
    
    let layout = UICollectionViewFlowLayout()
    layout.scrollDirection = .horizontal
    
    //CollectionCellView width autoSize
    layout.estimatedItemSize = UICollectionViewFlowLayout.automaticSize
    
    let collectionView = UICollectionView(frame: .zero, collectionViewLayout: layout)
    collectionView.translatesAutoresizingMaskIntoConstraints = false
    
    collectionView.register(CustomCollectionViewCell.self, forCellWithReuseIdentifier: cellId)
    collectionView.backgroundColor = .clear
    collectionView.delegate = self
    collectionView.dataSource = self
    collectionView.alwaysBounceHorizontal = true

//Add Spacing in each cell
    layout.minimumInteritemSpacing = 15
    layout.minimumLineSpacing = 15
    
    return collectionView
}()

我发现了使用IB配置单元格或行之间的间距的非常简单的方法。

只需从storyboard/Xib文件中选择UICollectionView，然后按下图所示单击大小检查器。

要以编程方式配置空间，请使用以下属性。

1)用于设置行间距。

[self.collectionView setMinimumLineSpacing:5];

2)用于设置项目/单元格之间的间距。

[self.collectionView setMinimumInteritemSpacing:5];