我有问题与接受的答案，所以我更新了它，这是为我工作:

.h

@interface MaxSpacingCollectionViewFlowLayout : UICollectionViewFlowLayout
@property (nonatomic,assign) CGFloat maxCellSpacing;
@end

.m

@implementation MaxSpacingCollectionViewFlowLayout

- (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect {
    NSArray *attributes = [super layoutAttributesForElementsInRect:rect];

    if (attributes.count <= 0) return attributes;

    CGFloat firstCellOriginX = ((UICollectionViewLayoutAttributes *)attributes[0]).frame.origin.x;

    for(int i = 1; i < attributes.count; i++) {
        UICollectionViewLayoutAttributes *currentLayoutAttributes = attributes[i];
        if (currentLayoutAttributes.frame.origin.x == firstCellOriginX) { // The first cell of a new row
            continue;
        }

        UICollectionViewLayoutAttributes *prevLayoutAttributes = attributes[i - 1];
        CGFloat prevOriginMaxX = CGRectGetMaxX(prevLayoutAttributes.frame);
        if ((currentLayoutAttributes.frame.origin.x - prevOriginMaxX) > self.maxCellSpacing) {
            CGRect frame = currentLayoutAttributes.frame;
            frame.origin.x = prevOriginMaxX + self.maxCellSpacing;
            currentLayoutAttributes.frame = frame;
        }
    }
    return attributes;
}

@end

在头文件中定义UICollectionViewDelegateFlowLayout协议。

实现UICollectionViewDelegateFlowLayout协议的如下方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView layout:(UICollectionViewLayout*)collectionViewLayout insetForSectionAtIndex:(NSInteger)section
{
    return UIEdgeInsetsMake(5, 5, 5, 5);
}

点击这里查看苹果文档的UIEdgeInsetMake方法。

我尝试了iago849的答案，它起作用了。

斯威夫特4

open override func layoutAttributesForElements(in rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
    guard let answer = super.layoutAttributesForElements(in: rect) else {
        return nil
    }
    let count = answer.count
    for i in 1..<count {
        let currentLayoutAttributes = answer[i]
        let prevLayoutAttributes = answer[i-1]
        let origin = prevLayoutAttributes.frame.maxX
        if (origin + CGFloat(spacing) + currentLayoutAttributes.frame.size.width) < self.collectionViewContentSize.width && currentLayoutAttributes.frame.origin.x > prevLayoutAttributes.frame.origin.x {
            var frame = currentLayoutAttributes.frame
            frame.origin.x = origin + CGFloat(spacing)
            currentLayoutAttributes.frame = frame
        }
    }
    return answer
}

这是github项目的链接。 https://github.com/vishalwaka/MultiTags

回答Swift 3.0, Xcode 8

1.确保你设置了集合视图委托

class DashboardViewController: UIViewController {
    @IBOutlet weak var dashboardCollectionView: UICollectionView!

    override func viewDidLoad() {
        super.viewDidLoad()
        dashboardCollectionView.delegate = self
    }
}

2.实现uicollectionviewdelegatflowlayout协议，而不是UICollectionViewDelegate。

extension DashboardViewController: UICollectionViewDelegateFlowLayout {
    fileprivate var sectionInsets: UIEdgeInsets {
        return .zero
    }

    fileprivate var itemsPerRow: CGFloat {
        return 2
    }

    fileprivate var interitemSpace: CGFloat {
        return 5.0
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        sizeForItemAt indexPath: IndexPath) -> CGSize {
        let sectionPadding = sectionInsets.left * (itemsPerRow + 1)
        let interitemPadding = max(0.0, itemsPerRow - 1) * interitemSpace
        let availableWidth = collectionView.bounds.width - sectionPadding - interitemPadding
        let widthPerItem = availableWidth / itemsPerRow

        return CGSize(width: widthPerItem, height: widthPerItem)
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        insetForSectionAt section: Int) -> UIEdgeInsets {
        return sectionInsets
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        minimumLineSpacingForSectionAt section: Int) -> CGFloat {
        return 0.0
    }

    func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumInteritemSpacingForSectionAt section: Int) -> CGFloat {
        return interitemSpace
    }
}

请注意属性名minimumInterItemSpacing。这将是项目之间的最小间距，而不是精确的间距。如果你设置minimumInterItemSpacing为某个值，你可以确保spacing不会小于该值。但有机会获得更高的价值。

实际上，项目之间的间距取决于几个因素itemSize和sectionInset。集合视图根据这些值动态放置内容。所以你不能保证精确的间距。你应该用sectionInset和minimumInterItemSpacing做一些试错。

如果你想在不影响实际单元格大小的情况下调整间距，这是最适合我的解决方案。#xcode 9 #tvOS11 #iOS11 #swift

在uicollectionviewdelegatflowlayout中，改变实现下一个方法，诀窍是你必须使用它们两个，文档并没有真正指向我去思考那个方向。: D

open func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumInteritemSpacingForSectionAt section: Int) -> CGFloat {
    return cellSpacing
}

public func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumLineSpacingForSectionAt section: Int) -> CGFloat {
    return cellSpacing
}