我有问题与接受的答案，所以我更新了它，这是为我工作:

.h

@interface MaxSpacingCollectionViewFlowLayout : UICollectionViewFlowLayout
@property (nonatomic,assign) CGFloat maxCellSpacing;
@end

.m

@implementation MaxSpacingCollectionViewFlowLayout

- (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect {
    NSArray *attributes = [super layoutAttributesForElementsInRect:rect];

    if (attributes.count <= 0) return attributes;

    CGFloat firstCellOriginX = ((UICollectionViewLayoutAttributes *)attributes[0]).frame.origin.x;

    for(int i = 1; i < attributes.count; i++) {
        UICollectionViewLayoutAttributes *currentLayoutAttributes = attributes[i];
        if (currentLayoutAttributes.frame.origin.x == firstCellOriginX) { // The first cell of a new row
            continue;
        }

        UICollectionViewLayoutAttributes *prevLayoutAttributes = attributes[i - 1];
        CGFloat prevOriginMaxX = CGRectGetMaxX(prevLayoutAttributes.frame);
        if ((currentLayoutAttributes.frame.origin.x - prevOriginMaxX) > self.maxCellSpacing) {
            CGRect frame = currentLayoutAttributes.frame;
            frame.origin.x = prevOriginMaxX + self.maxCellSpacing;
            currentLayoutAttributes.frame = frame;
        }
    }
    return attributes;
}

@end

我有一个水平的UICollectionView和子类化的UICollectionViewFlowLayout。集合视图具有较大的单元格，并且每次只显示一行单元格，并且集合视图适合屏幕的宽度。

我尝试了iago849的答案，它起作用了，但后来我发现我甚至不需要他的答案。出于某种原因，设置minimumInterItemSpacing没有任何作用。我的项目/单元格之间的间距可以完全由minimumlinespace控制。

不知道为什么会这样，但确实有效。

上面vojtech-vrbka的解决方案是正确的，但它会触发一个警告:

警告:UICollectionViewFlowLayout缓存的帧不匹配索引路径-缓存值:这可能是因为流布局子类layout是修改UICollectionViewFlowLayout返回的属性而没有复制它们

下面的代码应该修复它:

class CustomViewFlowLayout : UICollectionViewFlowLayout {

   let cellSpacing:CGFloat = 4

   override func layoutAttributesForElementsInRect(rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
       let original = super.layoutAttributesForElementsInRect(rect)

       if let original = original {
           let attributes = NSArray.init(array: original, copyItems: true) as! [UICollectionViewLayoutAttributes]

           for (index, attribute) in attributes.enumerate() {
                if index == 0 { continue }
                let prevLayoutAttributes = attributes[index - 1]
                let origin = CGRectGetMaxX(prevLayoutAttributes.frame)
                if(origin + cellSpacing + attribute.frame.size.width < self.collectionViewContentSize().width) {
                    attribute.frame.origin.x = origin + cellSpacing
                }
            }
            return attributes
       }
       return nil
   }
}

我在Swift 3单元格间距的解决方案，如Instagram:

lazy var collectionView: UICollectionView = {
    let layout = UICollectionViewFlowLayout()
    let cv = UICollectionView(frame: .zero, collectionViewLayout: layout)
    cv.backgroundColor = UIColor.rgb(red: 227, green: 227, blue: 227)
    cv.showsVerticalScrollIndicator = false
    layout.scrollDirection = .vertical
    layout.minimumLineSpacing = 1
    layout.minimumInteritemSpacing = 1
    return cv
}()

func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, sizeForItemAt indexPath: IndexPath) -> CGSize {

    switch UIDevice.current.modelName {
    case "iPhone 4":
        return CGSize(width: 106, height: 106)
    case "iPhone 5":
        return CGSize(width: 106, height: 106)
    case "iPhone 6,7":
        return CGSize(width: 124, height: 124)
    case "iPhone Plus":
        return CGSize(width: 137, height: 137)
    default:
        return CGSize(width: frame.width / 3, height: frame.width / 3)
    }
}

如何编程检测设备: https://stackoverflow.com/a/26962452/6013170

使用水平流布局，我也得到了10点之间的单元格间距。为了移除间距，我需要将minimumlinespespaces和minimumInterItemSpacing设置为零。

UICollectionViewFlowLayout *flow = [[UICollectionViewFlowLayout alloc] init];
flow.itemSize = CGSizeMake(cellWidth, cellHeight);
flow.scrollDirection = UICollectionViewScrollDirectionHorizontal;
flow.minimumInteritemSpacing = 0;
flow.minimumLineSpacing = 0;

此外，如果所有单元格大小相同，直接在流布局上设置属性比使用委托方法更简单、更有效。

我知道这个话题很老了，但如果有人还需要正确答案，你需要什么:

Override standard flow layout. Add implementation like that: - (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect { NSArray *answer = [super layoutAttributesForElementsInRect:rect]; for(int i = 1; i < [answer count]; ++i) { UICollectionViewLayoutAttributes *currentLayoutAttributes = answer[i]; UICollectionViewLayoutAttributes *prevLayoutAttributes = answer[i - 1]; NSInteger maximumSpacing = 4; NSInteger origin = CGRectGetMaxX(prevLayoutAttributes.frame); if(origin + maximumSpacing + currentLayoutAttributes.frame.size.width < self.collectionViewContentSize.width) { CGRect frame = currentLayoutAttributes.frame; frame.origin.x = origin + maximumSpacing; currentLayoutAttributes.frame = frame; } } return answer; }

其中maximumSpacing可以设置为您喜欢的任何值。这个技巧保证了单元格之间的空间将等于maximumSpacing!!