试试这个方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView
                    layout:(UICollectionViewLayout*)collectionViewLayout
    insetForSectionAtIndex:(NSInteger)section {

    UIEdgeInsets insets = UIEdgeInsetsMake(?, ?, ?, ?);

    return insets;
}

间距的简单代码

let layout = collectionView.collectionViewLayout as! UICollectionViewFlowLayout
layout.minimumInteritemSpacing = 10 // Some float value

我使用monotouch，所以名称和代码会有点不同，但你可以通过确保集合视图的宽度等于(x *单元格宽度)+ (x-1) * MinimumSpacing与x =每行单元格的数量来做到这一点。

只需要根据MinimumInteritemSpacing和Cell的宽度执行以下步骤

1)我们根据单元格大小+当前插入+最小间距计算每行项目的数量

float currentTotalWidth = CollectionView.Frame.Width - Layout.SectionInset.Left - Layout.SectionInset.Right (Layout = flowlayout)
int amountOfCellsPerRow = (currentTotalWidth + MinimumSpacing) / (cell width + MinimumSpacing)

2)现在你有了所有信息来计算集合视图的预期宽度

float totalWidth =(amountOfCellsPerRow * cell width) + (amountOfCellsPerRow-1) * MinimumSpacing

3)所以当前宽度与预期宽度之差为

float difference = currentTotalWidth - totalWidth;

4)现在调整insets(在本例中，我们将其添加到右侧，因此集合视图的左侧位置保持不变

Layout.SectionInset.Right = Layout.SectionInset.Right + difference;

投票的答案(以及快速版本)有一个小问题:右边会有一个很大的空格。

这是因为流布局是定制的，以使单元格间距精确，具有浮动左行为。

我的解决方案是操纵部分插入，使部分是对齐中心，但间距是完全指定的。

在下面的截图中，项目/行间距正好是8pt，而左右插入部分将大于8pt(使其居中对齐):

这样的Swift代码:

private let minItemSpacing: CGFloat = 8
private let itemWidth: CGFloat      = 100
private let headerHeight: CGFloat   = 32

override func viewDidLayoutSubviews() {
    super.viewDidLayoutSubviews()

    // Create our custom flow layout that evenly space out the items, and have them in the center
    let layout = UICollectionViewFlowLayout()
    layout.itemSize = CGSize(width: itemWidth, height: itemWidth)
    layout.minimumInteritemSpacing = minItemSpacing
    layout.minimumLineSpacing = minItemSpacing
    layout.headerReferenceSize = CGSize(width: 0, height: headerHeight)

    // Find n, where n is the number of item that can fit into the collection view
    var n: CGFloat = 1
    let containerWidth = collectionView.bounds.width
    while true {
        let nextN = n + 1
        let totalWidth = (nextN*itemWidth) + (nextN-1)*minItemSpacing
        if totalWidth > containerWidth {
            break
        } else {
            n = nextN
        }
    }

    // Calculate the section inset for left and right. 
    // Setting this section inset will manipulate the items such that they will all be aligned horizontally center.
    let inset = max(minItemSpacing, floor( (containerWidth - (n*itemWidth) - (n-1)*minItemSpacing) / 2 ) )
    layout.sectionInset = UIEdgeInsets(top: minItemSpacing, left: inset, bottom: minItemSpacing, right: inset)

    collectionView.collectionViewLayout = layout
}

在头文件中定义UICollectionViewDelegateFlowLayout协议。

实现UICollectionViewDelegateFlowLayout协议的如下方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView layout:(UICollectionViewLayout*)collectionViewLayout insetForSectionAtIndex:(NSInteger)section
{
    return UIEdgeInsetsMake(5, 5, 5, 5);
}

点击这里查看苹果文档的UIEdgeInsetMake方法。

回答Swift 3.0, Xcode 8

1.确保你设置了集合视图委托

class DashboardViewController: UIViewController {
    @IBOutlet weak var dashboardCollectionView: UICollectionView!

    override func viewDidLoad() {
        super.viewDidLoad()
        dashboardCollectionView.delegate = self
    }
}

2.实现uicollectionviewdelegatflowlayout协议，而不是UICollectionViewDelegate。

extension DashboardViewController: UICollectionViewDelegateFlowLayout {
    fileprivate var sectionInsets: UIEdgeInsets {
        return .zero
    }

    fileprivate var itemsPerRow: CGFloat {
        return 2
    }

    fileprivate var interitemSpace: CGFloat {
        return 5.0
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        sizeForItemAt indexPath: IndexPath) -> CGSize {
        let sectionPadding = sectionInsets.left * (itemsPerRow + 1)
        let interitemPadding = max(0.0, itemsPerRow - 1) * interitemSpace
        let availableWidth = collectionView.bounds.width - sectionPadding - interitemPadding
        let widthPerItem = availableWidth / itemsPerRow

        return CGSize(width: widthPerItem, height: widthPerItem)
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        insetForSectionAt section: Int) -> UIEdgeInsets {
        return sectionInsets
    }

    func collectionView(_ collectionView: UICollectionView,
                        layout collectionViewLayout: UICollectionViewLayout,
                        minimumLineSpacingForSectionAt section: Int) -> CGFloat {
        return 0.0
    }

    func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, minimumInteritemSpacingForSectionAt section: Int) -> CGFloat {
        return interitemSpace
    }
}