我遇到了同样的问题，问题是我在解决方案(Weband Droid)中有几个项目，即使在包管理器控制台中选择了默认项目，它也使用了Droid项目的连接字符串:

PM> update-database -Verbose
Using StartUp project 'Droid'. <-- DROID
Using NuGet project 'Web'. <-- WEB
Specify the '-Verbose' flag to view the SQL statements being applied to the target database.
<!-- BAD TARGET DATABASE -->
Target database is: 'DefaultConnection' (DataSource: .\SQLEXPRESS, Provider: System.Data.SqlClient, Origin: Convention).
System.Data.SqlClient.SqlException (0x80131904): A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: SQL Network Interfaces, error: 26 - Error Locating Server/Instance Specified)
   [REMOVED TEXT]
ClientConnectionId:00000000-0000-0000-0000-000000000000
Error Number:-1,State:0,Class:20
A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: SQL Network Interfaces, error: 26 - Error Locating Server/Instance Specified)

在包管理器控制台设置启动项目到Web和默认项目后，我得到了它的工作。

我发现以下技巧很有用:

Make sure your database engine is configured to accept remote connections: Start > All Programs > SQL Server 2005 > Configuration Tools > SQL Server Surface Area Configuration Click on Surface Area Configuration for Services and Connections Select the instance that is having a problem > Database Engine > Remote Connections Enable local and remote connections Restart instance You may need to create an exception on the firewall for the SQL Server instance and port you are using: Start > Run > Firewall.cpl Click on exceptions tab Add sqlservr.exe (typically located in C:\Program Files (x86)\Microsoft SQL Server\MSSQL.x\MSSQL\Bin, check your installs for the actual folder path) and port (default is 1433) Check your connection string as well From FIX : ERROR : Could not open a connection to SQL Server: Check if your SQL server services is up and running properly: Go to All Programs > Microsoft SQL Server 2008 > Configuration Tools > SQL Server Configuration Manager > SQL Server Services Check to make sure SQL Server service status is Running. In addition, ensure that your remote server is in the same network. Run sqlcmd -L to ascertain if your server is included in your network list. Enable TCP/IP in SQL Server Configuration When two or more SQL Servers are connected across network they do all communication using TCP/IP. The default port of SQL Server installation is 1433. This port can be changed through SQL Server Configuration Manager. TCP/IP should be enabled for SQL Server to be connected. Go to All Programs >> Microsoft SQL Server 2008 >> Configuration Tools >> SQL Server Configuration Manager >> Select TCP/IP Right Click on TCP/IP >> Click on Enable You must restart SQL Server Services for all the changes to take effect. Right click and go to menu properties to select location where default port of SQL Server can be changed.

I had the same issue after upgrading my Windows to Windows Pro 10 21H2. I have two SQL instances - 2014 and 2019 and I was not able to connect only to 2019 one. I restarted the computer, restarted all SQL related services. Two of the services were showing errors (SQL Server and SQL Server agent) and I was not able to start them. I could not also start these two services from C:\Windows\SysWOW64\SQLServerManager15.msc In the logs (C:\Program Files\Microsoft SQL Server\MSSQL15.MSSQLSERVER01\MSSQL\Log) I saw these lines:

Initializing the FallBack certificate failed with error code: 15, state: 29, error number: 0.
Error: 17190, Severity: 16, State: 1.
Unable to initialize SSL encryption because a valid certificate could not be found, and it is not possible to create a self-signed certificate.
Error: 17182, Severity: 16, State: 1.
TDSSNIClient initialization failed with error 0x80092004, status code 0x80. Reason: Unable to initialize SSL support. Cannot find object or property. 
Error: 17182, Severity: 16, State: 1.
TDSSNIClient initialization failed with error 0x80092004, status code 0x1. Reason: Initialization failed with an infrastructure error. Check for previous errors. Cannot find object or property. 
Error: 17826, Severity: 18, State: 3.
Could not start the network library because of an internal error in the network library. To determine the cause, review the errors immediately preceding this one in the error log.
Error: 17120, Severity: 16, State: 1.
SQL Server could not spawn FRunCommunicationsManager thread. Check the SQL Server error log and the operating system error log for information about possible related problems.

原来在升级后，服务的“Log On”属性(服务属性上的第二个选项卡)被设置为NT AUTHORITY\NETWORK SERVICES。当我将其更改为“本地系统帐户”时，我能够启动服务并连接到MS SQL 2019实例。

这个msdn论坛的帖子帮助我找到了这个。

您可以检查MS SQL Server 2014的服务状态。在Windows 7中，你可以这样做:

搜索并输入“SQL Server 2014配置管理器” 然后点击左侧菜单中的“SQL Server Service” 检查SQL Server实例的服务状态是否为“stopped”或“running” 如果已停止，请将状态改为“运行中”，并登录SQL Server Management Studio 2014

此错误主要发生在SQL服务停止时。您需要重新启动服务。要进入这个窗口，您必须像这样搜索服务-

然后搜索“SQLSERVER(MSSQLSERVER)”，并重新启动服务。

希望这能奏效。

如果你使用的是快速版:

您需要在服务器名称后添加\SQLEXPRESS

例如我的服务器\ SQLEXPRESS