我遇到了同样的问题，问题是我在解决方案(Weband Droid)中有几个项目，即使在包管理器控制台中选择了默认项目，它也使用了Droid项目的连接字符串:

PM> update-database -Verbose
Using StartUp project 'Droid'. <-- DROID
Using NuGet project 'Web'. <-- WEB
Specify the '-Verbose' flag to view the SQL statements being applied to the target database.
<!-- BAD TARGET DATABASE -->
Target database is: 'DefaultConnection' (DataSource: .\SQLEXPRESS, Provider: System.Data.SqlClient, Origin: Convention).
System.Data.SqlClient.SqlException (0x80131904): A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: SQL Network Interfaces, error: 26 - Error Locating Server/Instance Specified)
   [REMOVED TEXT]
ClientConnectionId:00000000-0000-0000-0000-000000000000
Error Number:-1,State:0,Class:20
A network-related or instance-specific error occurred while establishing a connection to SQL Server. The server was not found or was not accessible. Verify that the instance name is correct and that SQL Server is configured to allow remote connections. (provider: SQL Network Interfaces, error: 26 - Error Locating Server/Instance Specified)

在包管理器控制台设置启动项目到Web和默认项目后，我得到了它的工作。

即使我使用了正确的凭证，我也面临着这种问题。请务必执行以下操作。

确保您的sql server凭据。在sql server字段中，您必须使用计算机名。

要找到计算机名称，在您的计算机上搜索计算机名称，然后就可以找到计算机名称。然后粘贴并尝试连接。

如果无法正常工作，请尝试从服务启动计算机上的sql server。下面的截图会有帮助。

我将使用Entity Framework的项目设置为启动项目，然后运行update-database命令，解决了这个问题。

在尝试了所有的答案后，我把端口号(1433)放在服务器名后，用逗号插入连接字符串，为我工作。如下所示:

"Server=**.***.***.*\\MYSERVER,1433;Database=****;User Id=****;Password=*****;MultipleActiveResultSets=true;TrustServerCertificate=True"

我发现以下技巧很有用:

Make sure your database engine is configured to accept remote connections: Start > All Programs > SQL Server 2005 > Configuration Tools > SQL Server Surface Area Configuration Click on Surface Area Configuration for Services and Connections Select the instance that is having a problem > Database Engine > Remote Connections Enable local and remote connections Restart instance You may need to create an exception on the firewall for the SQL Server instance and port you are using: Start > Run > Firewall.cpl Click on exceptions tab Add sqlservr.exe (typically located in C:\Program Files (x86)\Microsoft SQL Server\MSSQL.x\MSSQL\Bin, check your installs for the actual folder path) and port (default is 1433) Check your connection string as well From FIX : ERROR : Could not open a connection to SQL Server: Check if your SQL server services is up and running properly: Go to All Programs > Microsoft SQL Server 2008 > Configuration Tools > SQL Server Configuration Manager > SQL Server Services Check to make sure SQL Server service status is Running. In addition, ensure that your remote server is in the same network. Run sqlcmd -L to ascertain if your server is included in your network list. Enable TCP/IP in SQL Server Configuration When two or more SQL Servers are connected across network they do all communication using TCP/IP. The default port of SQL Server installation is 1433. This port can be changed through SQL Server Configuration Manager. TCP/IP should be enabled for SQL Server to be connected. Go to All Programs >> Microsoft SQL Server 2008 >> Configuration Tools >> SQL Server Configuration Manager >> Select TCP/IP Right Click on TCP/IP >> Click on Enable You must restart SQL Server Services for all the changes to take effect. Right click and go to menu properties to select location where default port of SQL Server can be changed.

当我试图从其他网络访问mssql服务器时，我得到了解决方案:

Open "SQL Server Configuration Manager"

Now Click on "SQL Server Network Configuration" and Click on "Protocols for Name"

Right Click on "TCP/IP" (make sure it is Enabled) Click on Properties

Now Select "IP Addresses" Tab -and- Go to the last entry "IP All"

Enter "TCP Port" 1433

为1433端口添加入站+出站规则