您可以使用TTTAttributedLabel，它支持垂直对齐。

@property (nonatomic) TTTAttributedLabel* label;
<...>

//view's or viewController's init method
_label.verticalAlignment = TTTAttributedLabelVerticalAlignmentTop;

创建新类

标签顶部对齐

.h文件

#import <UIKit/UIKit.h>


@interface KwLabelTopAlign : UILabel {

}

@end

.m文件

#import "KwLabelTopAlign.h"


@implementation KwLabelTopAlign

- (void)drawTextInRect:(CGRect)rect {
    int lineHeight = [@"IglL" sizeWithFont:self.font constrainedToSize:CGSizeMake(rect.size.width, 9999.0f)].height;
    if(rect.size.height >= lineHeight) {
        int textHeight = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(rect.size.width, rect.size.height)].height;
        int yMax = textHeight;
        if (self.numberOfLines > 0) {
            yMax = MIN(lineHeight*self.numberOfLines, yMax);    
        }

        [super drawTextInRect:CGRectMake(rect.origin.x, rect.origin.y, rect.size.width, yMax)];
    }
}

@end

Edit

下面是一个更简单的实现，它也做到了这一点：

#import "KwLabelTopAlign.h"

@implementation KwLabelTopAlign

- (void)drawTextInRect:(CGRect)rect
{
    CGFloat height = [self.text sizeWithFont:self.font
                            constrainedToSize:rect.size
                                lineBreakMode:self.lineBreakMode].height;
    if (self.numberOfLines != 0) {
        height = MIN(height, self.font.lineHeight * self.numberOfLines);
    }
    rect.size.height = MIN(rect.size.height, height);
    [super drawTextInRect:rect];
}

@end

子类UILabel并约束绘图矩形，如下所示：

- (void)drawTextInRect:(CGRect)rect
{
    CGSize sizeThatFits = [self sizeThatFits:rect.size];
    rect.size.height = MIN(rect.size.height, sizeThatFits.height);

    [super drawTextInRect:rect];
}

我尝试了涉及换行填充的解决方案，在某些情况下遇到了错误的行为。根据我的经验，如上所述约束绘图矩形比使用numberOfLines更容易。

P.S.你可以想象一下这样轻松地支持UIViewContentMode：

- (void)drawTextInRect:(CGRect)rect
{
    CGSize sizeThatFits = [self sizeThatFits:rect.size];

    if (self.contentMode == UIViewContentModeTop) {
        rect.size.height = MIN(rect.size.height, sizeThatFits.height);
    }
    else if (self.contentMode == UIViewContentModeBottom) {
        rect.origin.y = MAX(0, rect.size.height - sizeThatFits.height);
        rect.size.height = MIN(rect.size.height, sizeThatFits.height);
    }

    [super drawTextInRect:rect];
}

您可以使用TTTAttributedLabel，它支持垂直对齐。

@property (nonatomic) TTTAttributedLabel* label;
<...>

//view's or viewController's init method
_label.verticalAlignment = TTTAttributedLabelVerticalAlignmentTop;

我发现这个问题的答案现在有点过时了，所以为汽车布局爱好者添加这个。

自动布局使这个问题变得非常微不足道。假设我们要将标签添加到UIView*视图中，以下代码将完成此操作：

UILabel *label = [[UILabel alloc] initWithFrame:CGRectZero];
[label setText:@"Some text here"];
[label setTranslatesAutoresizingMaskIntoConstraints:NO];
[view addSubview:label];

[view addConstraints:[NSLayoutConstraint constraintsWithVisualFormat:@"H:|[label]|" options:0 metrics:nil views:@{@"label": label}]];
[view addConstraints:[NSLayoutConstraint constraintsWithVisualFormat:@"V:|[label]" options:0 metrics:nil views:@{@"label": label}]];

标签的高度将自动计算（使用其intrinsicContentSize），标签将在视图顶部水平放置。

参考扩展解决方案：

for(int i=1; i< newLinesToPad; i++) 
    self.text = [self.text stringByAppendingString:@"\n"];

应替换为

for(int i=0; i<newLinesToPad; i++)
    self.text = [self.text stringByAppendingString:@"\n "];

每增加一行换行符都需要额外的空间，因为iPhone UILabels的尾部回车符似乎被忽略了：(

同样，alignBottom也应该用@“\n@%”代替“\n@”进行更新（对于周期初始化，也必须用“for（int i=0…”替换）。

以下扩展适用于我：

// -- file: UILabel+VerticalAlign.h
#pragma mark VerticalAlign
@interface UILabel (VerticalAlign)
- (void)alignTop;
- (void)alignBottom;
@end

// -- file: UILabel+VerticalAlign.m
@implementation UILabel (VerticalAlign)
- (void)alignTop {
    CGSize fontSize = [self.text sizeWithFont:self.font];
    double finalHeight = fontSize.height * self.numberOfLines;
    double finalWidth = self.frame.size.width;    //expected width of label
    CGSize theStringSize = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(finalWidth, finalHeight) lineBreakMode:self.lineBreakMode];
    int newLinesToPad = (finalHeight  - theStringSize.height) / fontSize.height;
    for(int i=0; i<newLinesToPad; i++)
        self.text = [self.text stringByAppendingString:@"\n "];
}

- (void)alignBottom {
    CGSize fontSize = [self.text sizeWithFont:self.font];
    double finalHeight = fontSize.height * self.numberOfLines;
    double finalWidth = self.frame.size.width;    //expected width of label
    CGSize theStringSize = [self.text sizeWithFont:self.font constrainedToSize:CGSizeMake(finalWidth, finalHeight) lineBreakMode:self.lineBreakMode];
    int newLinesToPad = (finalHeight  - theStringSize.height) / fontSize.height;
    for(int i=0; i<newLinesToPad; i++)
        self.text = [NSString stringWithFormat:@" \n%@",self.text];
}
@end

然后调用[yourLabel alignTop]；或[yourLabel alignBottom]；在每次标签文本分配后。