IE会缓存URL以加快加载速度，但如果你每隔一段时间轮询服务器以获取新信息，IE会缓存URL，并可能返回你一直拥有的相同数据集。

无论您最终如何执行GET请求——普通JavaScript、Prototype、jQuery等等——都要确保您设置了一种机制来对抗缓存。为了解决这个问题，在你要访问的URL末尾附加一个唯一的标记。这可以通过:

var sURL = '/your/url.html?' + (new Date()).getTime();

这将在URL的末尾附加一个唯一的时间戳，并将防止发生任何缓存。

<button type="button" onclick="loadXMLDoc()"> GET CONTENT</button>

 <script>
        function loadXMLDoc() {
            var xmlhttp = new XMLHttpRequest();
            var url = "<Enter URL>";``
            xmlhttp.onload = function () {
                if (xmlhttp.readyState == 4 && xmlhttp.status == "200") {
                    document.getElementById("demo").innerHTML = this.responseText;
                }
            }
            xmlhttp.open("GET", url, true);
            xmlhttp.send();
        }
    </script>

function get(path) {
    var form = document.createElement("form");
    form.setAttribute("method", "get");
    form.setAttribute("action", path);
    document.body.appendChild(form);
    form.submit();
}


get('/my/url/')

同样的事情也可以为post request做。 看看这个链接JavaScript post请求像一个表单提交

一种支持旧浏览器的解决方案:

function httpRequest() {
    var ajax = null,
        response = null,
        self = this;

    this.method = null;
    this.url = null;
    this.async = true;
    this.data = null;

    this.send = function() {
        ajax.open(this.method, this.url, this.asnyc);
        ajax.send(this.data);
    };

    if(window.XMLHttpRequest) {
        ajax = new XMLHttpRequest();
    }
    else if(window.ActiveXObject) {
        try {
            ajax = new ActiveXObject("Msxml2.XMLHTTP.6.0");
        }
        catch(e) {
            try {
                ajax = new ActiveXObject("Msxml2.XMLHTTP.3.0");
            }
            catch(error) {
                self.fail("not supported");
            }
        }
    }

    if(ajax == null) {
        return false;
    }

    ajax.onreadystatechange = function() {
        if(this.readyState == 4) {
            if(this.status == 200) {
                self.success(this.responseText);
            }
            else {
                self.fail(this.status + " - " + this.statusText);
            }
        }
    };
}

这段代码可能有点过分，但绝对是安全的。

用法:

//create request with its porperties
var request = new httpRequest();
request.method = "GET";
request.url = "https://example.com/api?parameter=value";

//create callback for success containing the response
request.success = function(response) {
    console.log(response);
};

//and a fail callback containing the error
request.fail = function(error) {
    console.log(error);
};

//and finally send it away
request.send();

简单的异步请求:

function get(url, callback) {
  var getRequest = new XMLHttpRequest();

  getRequest.open("get", url, true);

  getRequest.addEventListener("readystatechange", function() {
    if (getRequest.readyState === 4 && getRequest.status === 200) {
      callback(getRequest.responseText);
    }
  });

  getRequest.send();
}

为了刷新来自joann的最佳答案，这是我的代码:

let httpRequestAsync = (method, url) => {
    return new Promise(function (resolve, reject) {
        var xhr = new XMLHttpRequest();
        xhr.open(method, url);
        xhr.onload = function () {
            if (xhr.status == 200) {
                resolve(xhr.responseText);
            }
            else {
                reject(new Error(xhr.responseText));
            }
        };
        xhr.send();
    });
}