正如@SalCelli提到的，chrome://restart工作。但是，这会重新启动所有的选项卡。

另一种方法是采用CEGRD建议的隐身模式

但是，如果你不喜欢在Chrome 86 (Mac)上重新启动和隐身使用，我发现@opsb和Mike提供的答案只适用于以下额外步骤。

Enter the wrong username in the url without the resources eg: if the url is http://mywebsite.com/resources/, it will not work if I enter http://wrong@mywebsite.com/resources/, but will work if I enter only http://wrong@mywebsite.com/ it clears the Basic Auth credentials prompt for the credentials again However, entering the valid credentials will not work, as in the background, chrome still send the wrong user as part of the url, even though the url appears right in the address bar When prompted for credentials you would need to Cancel, and click the address bar and reload the page from pressing enter. Now enter the correct password

Chrome使用与IE相同的Internet选项。

试着打开你的互联网选项并从“可信站点”中删除URL。当您重新启动浏览器并再次访问该URL时，这将重新生成一个401凭据调用。

您可能还需要将其从“内部网站点”中删除。

对于Windows 10:对我有用的是在凭据管理器中清除Windows凭据中的凭据。

只做

https://newUsername:newPassword@example.com

.．.重写你的旧凭证。

退出Chrome时，身份验证将被清除。

Note however, that by default Chrome is running apps in the background, so it may not really exit even if you close all Chrome windows. You can either change this behavior under advanced setting, or e.g. under Windows, you can completely exit Chrome by using the Chrome icon in the systray. There should be an icon if Chrome is still running, but maybe you'll find it only in the popup with the hidden icons. The context menu of the Chrome icon has an entry to completely exit Chrome, and you can also change the setting for running apps in the background using that menu.

打开Chrome菜单 选择设置 滚动到底部 单击“显示高级设置…” 滚动到底部 在“系统”下取消选中“当谷歌Chrome浏览器关闭时继续运行后台应用程序”的复选框

这并不是问题所要问的，但如果你不小心保存了基本的认证凭据，想要清除或更新它们:

https://support.google.com/accounts/answer/6197437

开放的Chrome。 在右上角，单击“更多>”，然后单击“设置”。 在底部，单击Advanced。 在“密码和表单”下，单击“管理密码”。 在“已保存的密码”下，单击要清除已保存的基本身份验证凭据的站点上的删除。

步骤1-4可以通过这个链接快速导航:chrome://settings/passwords

这在Chrome版本59.0.3071.115中工作