您可以使用Python的“OS”图书馆:

>>> import os
>>> os.path.exists("C:\\Users\\####\\Desktop\\test.txt") 
True
>>> os.path.exists("C:\\Users\\####\\Desktop\\test.tx")
False

import os
os.path.exists(path) # Returns whether the path (directory or file) exists or not
os.path.isfile(path) # Returns whether the file exists or not

您可以使用Python的“OS”图书馆:

>>> import os
>>> os.path.exists("C:\\Users\\####\\Desktop\\test.txt") 
True
>>> os.path.exists("C:\\Users\\####\\Desktop\\test.tx")
False

你可以尝试一下(更安全):

try:
    # http://effbot.org/zone/python-with-statement.htm
    # 'with' is safer to open a file
    with open('whatever.txt') as fh:
        # Do something with 'fh'
except IOError as e:
    print("({})".format(e))

奥普特将是:

(没有此类文件或目录:‘whatever.txt’)

然后,取决于结果,你的程序可以只是从那里继续运行,或者你可以编码阻止它,如果你愿意。

if os.path.isfile(path_to_file):
    try:
        open(path_to_file)
            pass
    except IOError as e:
        print "Unable to open file"

提取例外被认为是一个可接受的,和 Pythonic,方法的流量控制在您的程序. 考虑处理错误的文件与 IOErrors. 在这种情况下,一个 IOError 例外将被提取,如果文件存在,但用户没有阅读许可。

来源:使用Python:如何检查是否存在文件

import os.path

def isReadableFile(file_path, file_name):
    full_path = file_path + "/" + file_name
    try:
        if not os.path.exists(file_path):
            print "File path is invalid."
            return False
        elif not os.path.isfile(full_path):
            print "File does not exist."
            return False
        elif not os.access(full_path, os.R_OK):
            print "File cannot be read."
            return False
        else:
            print "File can be read."
            return True
    except IOError as ex:
        print "I/O error({0}): {1}".format(ex.errno, ex.strerror)
    except Error as ex:
        print "Error({0}): {1}".format(ex.errno, ex.strerror)
    return False
#------------------------------------------------------

path = "/usr/khaled/documents/puzzles"
fileName = "puzzle_1.txt"

isReadableFile(path, fileName)