/*
 * As terse as possible, assuming you're using ES version 6+
 */
var upLetter1=s=>s.replace(/./,m=>m.toUpperCase());

console.log(upLetter1("the quick brown fox jumped over the lazy dog."));
//\\ The quick brown fox jumped over the lazy dog. //\\

我更喜欢使用一个以功能方式为导向的解决方案(例如地图序列):

Array.from(str).map((letter, i) => i === 0 ? letter.toUpperCase() : letter ).join('');

var a = "this is a test"
console.log(a.replace(/^[a-z]/g, txt => txt.toUpperCase()));

如果你需要所有的字母,从一个字母开始,你可以使用以下函数:

const capitalLetters = (s) => {
    return s.trim().split(" ").map(i => i[0].toUpperCase() + i.substr(1)).reduce((ac, i) => `${ac} ${i}`);
}

例子:

console.log(`result: ${capitalLetters("this is a test")}`)
// Result: "This Is A Test"

string = string.replace(string.charAt(0), string.charAt(0).toUpperCase());

有一个非常简单的方式来实现它通过替代。

'foo'.replace(/^./, str => str.toUpperCase())

结果:

'Foo'