onInputChange(evt) {
    var tgt = evt.target || window.event.srcElement,
    files = tgt.files;
    if (FileReader && files && files.length) {
        var fr = new FileReader();
        fr.onload = function () {
            var base64 = fr.result;
            debugger;
        }
        fr.readAsDataURL(files[0]);
    }
}

现代ES6路(异步/await)

const toBase64 = file => new Promise((resolve, reject) => {
    const reader = new FileReader();
    reader.readAsDataURL(file);
    reader.onload = () => resolve(reader.result);
    reader.onerror = error => reject(error);
});

async function Main() {
   const file = document.querySelector('#myfile').files[0];
   console.log(await toBase64(file));
}

Main();

UPD:

如果你想捕捉错误

async function Main() {
   const file = document.querySelector('#myfile').files[0];
   try {
      const result = await toBase64(file);
      return result
   } catch(error) {
      console.error(error);
      return;
   }
   //...
}

这是

// fileObj: File
const base64 = window.URL.createObjectURL(fileObj);

// You can use it with <img src={base64} />

在德米特里·帕夫卢汀和乔舒亚的基础上。下面是一个扩展版本，它提取base64内容(在开始时删除元数据)，并确保正确地进行填充。

function getBase64(file) {
  return new Promise((resolve, reject) => {
    const reader = new FileReader();
    reader.readAsDataURL(file);
    reader.onload = () => {
      let encoded = reader.result.toString().replace(/^data:(.*,)?/, '');
      if ((encoded.length % 4) > 0) {
        encoded += '='.repeat(4 - (encoded.length % 4));
      }
      resolve(encoded);
    };
    reader.onerror = error => reject(error);
  });
}

打印稿版本

const file2Base64 = (file:File):Promise<string> => {
    return new Promise<string> ((resolve,reject)=> {
         const reader = new FileReader();
         reader.readAsDataURL(file);
         reader.onload = () => resolve(reader.result?.toString() || '');
         reader.onerror = error => reject(error);
     })
    }

我用过这个简单的方法，而且效果很好

 function  uploadImage(e) {
  var file = e.target.files[0];
    let reader = new FileReader();
    reader.onload = (e) => {
    let image = e.target.result;
    console.log(image);
    };
  reader.readAsDataURL(file);
  
}