i='I want a hIPpo for my birthday'
key='hippo'
swp='giraffe'

o=(i.lower().split(key))
c=0
p=0
for w in o:
    o[c]=i[p:p+len(w)]
    p=p+len(key+w)
    c+=1
print(swp.join(o))

在一行中:

import re
re.sub("(?i)hello","bye", "hello HeLLo HELLO") #'bye bye bye'
re.sub("(?i)he\.llo","bye", "he.llo He.LLo HE.LLO") #'bye bye bye'

或者，使用可选的"flags"参数:

import re
re.sub("hello", "bye", "hello HeLLo HELLO", flags=re.I) #'bye bye bye'
re.sub("he\.llo", "bye", "he.llo He.LLo HE.LLO", flags=re.I) #'bye bye bye'

这并不需要RegularExp

def ireplace(old, new, text):
    """ 
    Replace case insensitive
    Raises ValueError if string not found
    """
    index_l = text.lower().index(old.lower())
    return text[:index_l] + new + text[index_l + len(old):] 

import re
pattern = re.compile("hello", re.IGNORECASE)
pattern.sub("bye", "hello HeLLo HELLO")
# 'bye bye bye'

i='I want a hIPpo for my birthday'
key='hippo'
swp='giraffe'

o=(i.lower().split(key))
c=0
p=0
for w in o:
    o[c]=i[p:p+len(w)]
    p=p+len(key+w)
    c+=1
print(swp.join(o))

继续bFloch的回答，这个函数将以不区分大小写的方式改变旧与新，而不是一个。

def ireplace(old, new, text):
    idx = 0
    while idx < len(text):
        index_l = text.lower().find(old.lower(), idx)
        if index_l == -1:
            return text
        text = text[:index_l] + new + text[index_l + len(old):]
        idx = index_l + len(new) 
    return text