在反复折腾之后，我发现这是最稳定的解决方案:

var dropzoneId = "dropzone"; window.addEventListener("dragenter", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }, false); window.addEventListener("dragover", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }); window.addEventListener("drop", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }); <div id="dropzone">...</div>

在窗口上无条件地设置effectAllow和dropEffect会导致我的drop zone不再接受任何d-n-d，无论属性是否设置为新的。

在反复折腾之后，我发现这是最稳定的解决方案:

var dropzoneId = "dropzone"; window.addEventListener("dragenter", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }, false); window.addEventListener("dragover", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }); window.addEventListener("drop", function(e) { if (e.target.id != dropzoneId) { e.preventDefault(); e.dataTransfer.effectAllowed = "none"; e.dataTransfer.dropEffect = "none"; } }); <div id="dropzone">...</div>

在窗口上无条件地设置effectAllow和dropEffect会导致我的drop zone不再接受任何d-n-d，无论属性是否设置为新的。

为了它的价值，我使用以下。如果不是特别优雅的话，可能会很好，很明确?

var myDropZone = document.getElementById('drop_zone');

// first, inhibit the default behaviour throughout the window
window.addEventListener('drop', () => { 
  event.preventDefault(); 
} );
window.addEventListener('dragover', () => { 
  event.dataTransfer.dropEffect = 'none'; // dont allow drops
  event.preventDefault(); 
} );

// Next, allow the cursor to show 'copy' as it is dragged over 
// my drop zone but dont forget to stop the event propagating

myDropZone.addEventListener('dragover', () => { 
  event.dataTransfer.dropEffect = 'copy';
  event.stopPropagation(); // important !!
  event.preventDefault();
} );

// In my drop zone, deal with files as they are dropped
myDropZone.addEventListener('drop', myDropHandler);

您可以向窗口添加一个事件监听器，在所有拖放事件上调用preventDefault()。 例子:

window.addEventListener("dragover",function(e){
  e = e || event;
  e.preventDefault();
},false);
window.addEventListener("drop",function(e){
  e = e || event;
  e.preventDefault();
},false);

我使用类选择器为多个上传区域，所以我的解决方案采取了这种不那么纯粹的形式

基于Axel Amthor的答案，依赖jQuery(别名为$)

_stopBrowserFromOpeningDragAndDropPDFFiles = function () {

        _preventDND = function(e) {
            if (!$(e.target).is($(_uploadBoxSelector))) {
                e.preventDefault();
                e.dataTransfer.effectAllowed = 'none';
                e.dataTransfer.dropEffect = 'none';
            }
        };

        window.addEventListener('dragenter', function (e) {
            _preventDND(e);
        }, false);

        window.addEventListener('dragover', function (e) {
            _preventDND(e);
        });

        window.addEventListener('drop', function (e) {
            _preventDND(e);
        });
    },

jQuery的正确答案将是:

$(document).on({
    dragover: function() {
        return false;
    },
    drop: function() {
        return false;
    }
});

这里返回false将表现为event.preventDefault()和event.stopPropagation()。