仅使用pip的跨平台支持:

#!/usr/bin/env python

from sys import stderr
from pip.commands.uninstall import UninstallCommand
from pip import get_installed_distributions

pip_uninstall = UninstallCommand()
options, args = pip_uninstall.parse_args([
    package.project_name
    for package in
    get_installed_distributions()
    if not package.location.endswith('dist-packages')
])

options.yes = True  # Don't confirm before uninstall
# set `options.require_venv` to True for virtualenv restriction

try:
    print pip_uninstall.run(options, args)
except OSError as e:
    if e.errno != 13:
        raise e
    print >> stderr, "You lack permissions to uninstall this package.
                      Perhaps run with sudo? Exiting."
    exit(13)
# Plenty of other exceptions can be thrown, e.g.: `InstallationError`
# handle them if you want to.

使用virtualenvwrapper函数:

wipeenv

参见wipeenv文档

如果你正在使用pew，你可以使用wipeenv命令:

皮尤wipeenv[环境]

我做到了以下几点:

用当前安装的包列表创建名为reqs.txt的需求文件

pip freeze > reqs.txt

然后卸载reqs.txt中的所有包

# -y means remove the package without prompting for confirmation
pip uninstall -y -r reqs.txt

我喜欢这种方法，因为如果你犯了错误，你总是有一个pip需求文件可以依靠。它也是可重复的，而且是跨平台的(Windows、Linux、MacOs)。

仅使用pip的跨平台支持:

#!/usr/bin/env python

from sys import stderr
from pip.commands.uninstall import UninstallCommand
from pip import get_installed_distributions

pip_uninstall = UninstallCommand()
options, args = pip_uninstall.parse_args([
    package.project_name
    for package in
    get_installed_distributions()
    if not package.location.endswith('dist-packages')
])

options.yes = True  # Don't confirm before uninstall
# set `options.require_venv` to True for virtualenv restriction

try:
    print pip_uninstall.run(options, args)
except OSError as e:
    if e.errno != 13:
        raise e
    print >> stderr, "You lack permissions to uninstall this package.
                      Perhaps run with sudo? Exiting."
    exit(13)
# Plenty of other exceptions can be thrown, e.g.: `InstallationError`
# handle them if you want to.

就我而言，我意外地在macOS上使用homebrew安装的pip在全球范围内安装了许多软件包。恢复到默认包的最简单方法是:

$ brew reinstall python

或者，如果你使用pip3:

$ brew reinstall python3