我得到了它的工作组合的答案:

[[[button titleLabel] layer] removeAllAnimations];

    [UIView performWithoutAnimation:^{

        [button setTitle:@"Title" forState:UIControlStateNormal];

    }];

结合以上的答案，可以为UIButtonTypeSystem提供以下解决方案:

if (_button.enabled)
{
    [UIView setAnimationsEnabled:NO];
    [_button setTitle:@"title" forState:UIControlStateNormal];
    [UIView setAnimationsEnabled:YES];
}
else // disabled
{
    [UIView setAnimationsEnabled:NO];
    _button.enabled = YES;
    [_button setTitle:@"title" forState:UIControlStateNormal];
    _button.enabled = NO;
    [UIView setAnimationsEnabled:YES];
}

Xhacker Liu扩展转换为Swift 3:

extension UIButton {
    func setTitleWithoutAnimation(title: String?) {
        UIView.setAnimationsEnabled(false)

        setTitle(title, for: .normal)

        layoutIfNeeded()
        UIView.setAnimationsEnabled(true)
    }
}

将按钮类型设置为UIButtonTypeCustom，它将停止闪烁

我已经做了一个Swift扩展来做这个:

extension UIButton {
    func setTitleWithoutAnimation(title: String?) {
        UIView.setAnimationsEnabled(false)

        setTitle(title, forState: .Normal)

        layoutIfNeeded()
        UIView.setAnimationsEnabled(true)
    }
}

适用于我的iOS 8和9，与UIButtonTypeSystem。

(代码是Swift 2, Swift 3和Objective-C应该类似)

使用performWithoutAnimation:方法，然后强制布局立即发生，而不是稍后。

[UIView performWithoutAnimation:^{
  [self.myButton setTitle:text forState:UIControlStateNormal];
  [self.myButton layoutIfNeeded];
}];