编辑：查看@Blair Conrad的答案以获得更清洁的解决方案

>>> import datetime
>>> datetime.date(2000, 2, 1) - datetime.timedelta(days=1)
datetime.date(2000, 1, 31)

>>> import datetime
>>> import calendar
>>> date  = datetime.datetime.now()

>>> print date
2015-03-06 01:25:14.939574

>>> print date.replace(day = 1)
2015-03-01 01:25:14.939574

>>> print date.replace(day = calendar.monthrange(date.year, date.month)[1])
2015-03-31 01:25:14.939574

from datetime import timedelta
(any_day.replace(day=1) + timedelta(days=32)).replace(day=1) - timedelta(days=1)

我喜欢这样

import datetime
import calendar

date=datetime.datetime.now()
month_end_date=datetime.datetime(date.year,date.month,1) + datetime.timedelta(days=calendar.monthrange(date.year,date.month)[1] - 1)

另一个解决方案是这样做：

from datetime import datetime

def last_day_of_month(year, month):
    """ Work out the last day of the month """
    last_days = [31, 30, 29, 28, 27]
    for i in last_days:
        try:
            end = datetime(year, month, i)
        except ValueError:
            continue
        else:
            return end.date()
    return None

使用如下函数：

>>> 
>>> last_day_of_month(2008, 2)
datetime.date(2008, 2, 29)
>>> last_day_of_month(2009, 2)
datetime.date(2009, 2, 28)
>>> last_day_of_month(2008, 11)
datetime.date(2008, 11, 30)
>>> last_day_of_month(2008, 12)
datetime.date(2008, 12, 31)

calendar.monthrange提供以下信息：

日历.月范围（年，月）返回指定年份和月份的月份第一天的工作日和月份天数。

>>> import calendar
>>> calendar.monthrange(2002, 1)
(1, 31)
>>> calendar.monthrange(2008, 2)  # leap years are handled correctly
(4, 29)
>>> calendar.monthrange(2100, 2)  # years divisible by 100 but not 400 aren't leap years
(0, 28)

so:

calendar.monthrange(year, month)[1]

似乎是最简单的方法。