简单地说，这在“所有浏览器”(特别是IE8/7)上都兼容:

function createClass(name,rules){
    var style = document.createElement('style');
    style.type = 'text/css';
    document.getElementsByTagName('head')[0].appendChild(style);
    if(!(style.sheet||{}).insertRule) 
        (style.styleSheet || style.sheet).addRule(name, rules);
    else
        style.sheet.insertRule(name+"{"+rules+"}",0);
}
createClass('.whatever',"background-color: green;");

最后一位将类应用于一个元素:

function applyClass(name,element,doRemove){
    if(typeof element.valueOf() == "string"){
        element = document.getElementById(element);
    }
    if(!element) return;
    if(doRemove){
        element.className = element.className.replace(new RegExp("\\b" + name + "\\b","g"));
    }else{      
        element.className = element.className + " " + name;
    }
}

这里还有一个小测试页面:https://gist.github.com/shadybones/9816763

关键的一点是，样式元素有一个“styleSheet”/“sheet”属性，你可以用它来添加/删除规则。

IE 9。现在可以加载文本文件并设置样式。innerHTML属性。所以本质上你现在可以通过ajax加载一个css文件(并获得回调)，然后像这样设置样式标签内的文本。

这适用于其他浏览器，不确定多久以前。但只要你不需要支持IE8，它就可以工作。

// RESULT: doesn't work in IE8 and below. Works in IE9 and other browsers.
$(document).ready(function() {
    // we want to load the css as a text file and append it with a style.
    $.ajax({
        url:'myCss.css',
        success: function(result) {
            var s = document.createElement('style');
            s.setAttribute('type', 'text/css');
            s.innerHTML = result;
            document.getElementsByTagName("head")[0].appendChild(s);
        },
        fail: function() {
            alert('fail');
        }
    })
});

然后你可以让它取出一个外部文件，比如mycss。css

.myClass { background:#F00; }

我在这里看了一些答案，我找不到任何自动添加一个新的样式表，如果没有，如果不是简单地修改一个现有的已经包含所需的样式，所以我做了一个新函数(应该跨所有浏览器工作，虽然没有测试，使用addRule和除了基本的本地JavaScript，让我知道它是否工作):

function myCSS(data) {
    var head = document.head || document.getElementsByTagName("head")[0];
    if(head) {
        if(data && data.constructor == Object) {
            for(var k in data) {
                var selector = k;
                var rules = data[k];

                var allSheets = document.styleSheets;
                var cur = null;

                var indexOfPossibleRule = null,
                    indexOfSheet = null;
                for(var i = 0; i < allSheets.length; i++) {
                    indexOfPossibleRule = findIndexOfObjPropInArray("selectorText",selector,allSheets[i].cssRules);
                    if(indexOfPossibleRule != null) {
                        indexOfSheet = i;
                        break;
                    }
                }

                var ruleToEdit = null;
                if(indexOfSheet != null) {

                    ruleToEdit = allSheets[indexOfSheet].cssRules[indexOfPossibleRule];

                } else {
                    cur = document.createElement("style");
                    cur.type =  "text/css";
                    head.appendChild(cur);
                    cur.sheet.addRule(selector,"");
                    ruleToEdit = cur.sheet.cssRules[0];
                    console.log("NOPE, but here's a new one:", cur);
                }
                applyCustomCSSruleListToExistingCSSruleList(rules, ruleToEdit, (err) => {
                    if(err) {
                        console.log(err);
                    } else {
                        console.log("successfully added ", rules, " to ", ruleToEdit);
                    }
                });
            }
        } else {
            console.log("provide one paramter as an object containing the cssStyles, like: {\"#myID\":{position:\"absolute\"}, \".myClass\":{background:\"red\"}}, etc...");
        }
    } else {
        console.log("run this after the page loads");
    }

};  

然后在上面的函数中或其他任何地方添加这两个helper函数:

function applyCustomCSSruleListToExistingCSSruleList(customRuleList, existingRuleList, cb) {
    var err = null;
    console.log("trying to apply ", customRuleList, " to ", existingRuleList);
    if(customRuleList && customRuleList.constructor == Object && existingRuleList && existingRuleList.constructor == CSSStyleRule) {
        for(var k in customRuleList) {
            existingRuleList["style"][k] = customRuleList[k];
        }

    } else {
        err = ("provide first argument as an object containing the selectors for the keys, and the second argument is the CSSRuleList to modify");
    }
    if(cb) {
        cb(err);
    }
}

function findIndexOfObjPropInArray(objPropKey, objPropValue, arr) {
    var index = null;
    for(var i = 0; i < arr.length; i++) {
        if(arr[i][objPropKey] == objPropValue) {
            index = i;
            break;
        }
    }
    return index;
}

(注意，在它们中我都使用了for循环而不是.filter，因为CSS样式/规则列表类只有一个length属性，而没有.filter方法。)

然后叫它:

myCSS({
    "#coby": {
        position:"absolute",
        color:"blue"
    },
    ".myError": {
        padding:"4px",
        background:"salmon"
    }
})

让我知道它是否适用于您的浏览器或给出一个错误。

找到了一个更好的解决方案，它适用于所有浏览器。 使用文档。样式表来添加或替换规则。公认的答案是简短和方便的，但这适用于IE8和更少。

function createCSSSelector (selector, style) {
  if (!document.styleSheets) return;
  if (document.getElementsByTagName('head').length == 0) return;

  var styleSheet,mediaType;

  if (document.styleSheets.length > 0) {
    for (var i = 0, l = document.styleSheets.length; i < l; i++) {
      if (document.styleSheets[i].disabled) 
        continue;
      var media = document.styleSheets[i].media;
      mediaType = typeof media;

      if (mediaType === 'string') {
        if (media === '' || (media.indexOf('screen') !== -1)) {
          styleSheet = document.styleSheets[i];
        }
      }
      else if (mediaType=='object') {
        if (media.mediaText === '' || (media.mediaText.indexOf('screen') !== -1)) {
          styleSheet = document.styleSheets[i];
        }
      }

      if (typeof styleSheet !== 'undefined') 
        break;
    }
  }

  if (typeof styleSheet === 'undefined') {
    var styleSheetElement = document.createElement('style');
    styleSheetElement.type = 'text/css';
    document.getElementsByTagName('head')[0].appendChild(styleSheetElement);

    for (i = 0; i < document.styleSheets.length; i++) {
      if (document.styleSheets[i].disabled) {
        continue;
      }
      styleSheet = document.styleSheets[i];
    }

    mediaType = typeof styleSheet.media;
  }

  if (mediaType === 'string') {
    for (var i = 0, l = styleSheet.rules.length; i < l; i++) {
      if(styleSheet.rules[i].selectorText && styleSheet.rules[i].selectorText.toLowerCase()==selector.toLowerCase()) {
        styleSheet.rules[i].style.cssText = style;
        return;
      }
    }
    styleSheet.addRule(selector,style);
  }
  else if (mediaType === 'object') {
    var styleSheetLength = (styleSheet.cssRules) ? styleSheet.cssRules.length : 0;
    for (var i = 0; i < styleSheetLength; i++) {
      if (styleSheet.cssRules[i].selectorText && styleSheet.cssRules[i].selectorText.toLowerCase() == selector.toLowerCase()) {
        styleSheet.cssRules[i].style.cssText = style;
        return;
      }
    }
    styleSheet.insertRule(selector + '{' + style + '}', styleSheetLength);
  }
}

函数的用法如下。

createCSSSelector('.mycssclass', 'display:none');

一个可以帮助您完成任务的有趣项目是JSS。

JSS是一个CSS的创作工具，它允许你使用JavaScript以一种声明性的、无冲突的和可重用的方式描述样式。它可以在浏览器、服务器端或在构建时在Node中编译。

JSS库允许您使用.attach()函数在DOM/head部分中进行注入。

Repl在线版本评估。

更多关于JSS的信息。

一个例子:

// Use plugins.
jss.use(camelCase())

// Create your style.
const style = {
  myButton: {
    color: 'green'
  }
}

// Compile styles, apply plugins.
const sheet = jss.createStyleSheet(style)

// If you want to render on the client, insert it into DOM.
sheet.attach()

YUI拥有迄今为止我所见过的最好的样式表实用程序。我鼓励你去看看，但这里有一个味道:

// style element or locally sourced link element
var sheet = YAHOO.util.StyleSheet(YAHOO.util.Selector.query('style',null,true));

sheet = YAHOO.util.StyleSheet(YAHOO.util.Dom.get('local'));


// OR the id of a style element or locally sourced link element
sheet = YAHOO.util.StyleSheet('local');


// OR string of css text
var css = ".moduleX .alert { background: #fcc; font-weight: bold; } " +
          ".moduleX .warn  { background: #eec; } " +
          ".hide_messages .moduleX .alert, " +
          ".hide_messages .moduleX .warn { display: none; }";

sheet = new YAHOO.util.StyleSheet(css);

There are obviously other much simpler ways of changing styles on the fly such as those suggested here. If they make sense for your problem, they might be best, but there are definitely reasons why modifying CSS is a better solution. The most obvious case is when you need to modify a large number of elements. The other major case is if you need your style changes to involve the cascade. Using the DOM to modify an element will always have a higher priority. It's the sledgehammer approach and is equivalent to using the style attribute directly on the HTML element. That is not always the desired effect.