以下是上述Ryan Artecona解决方案的一些修改。

function myGetPxStyle(e,p)
{
    var r=window.getComputedStyle?window.getComputedStyle(e,null)[p]:"";
    return parseFloat(r);
}

function myGetClick=function(ev)
{
    // {x:ev.layerX,y:ev.layerY} doesn't work when zooming with mac chrome 27
    // {x:ev.clientX,y:ev.clientY} not supported by mac firefox 21
    // document.body.scrollLeft and document.body.scrollTop seem required when scrolling on iPad
    // html is not an offsetParent of body but can have non null offsetX or offsetY (case of wordpress 3.5.1 admin pages for instance)
    // html.offsetX and html.offsetY don't work with mac firefox 21

    var offsetX=0,offsetY=0,e=this,x,y;
    var htmls=document.getElementsByTagName("html"),html=(htmls?htmls[0]:0);

    do
    {
        offsetX+=e.offsetLeft-e.scrollLeft;
        offsetY+=e.offsetTop-e.scrollTop;
    } while (e=e.offsetParent);

    if (html)
    {
        offsetX+=myGetPxStyle(html,"marginLeft");
        offsetY+=myGetPxStyle(html,"marginTop");
    }

    x=ev.pageX-offsetX-document.body.scrollLeft;
    y=ev.pageY-offsetY-document.body.scrollTop;
    return {x:x,y:y};
}

下面是对Ryan Artecona关于画布宽度可变(%)的答案的一个小修改:

 HTMLCanvasElement.prototype.relMouseCoords = function (event) {
    var totalOffsetX = 0;
    var totalOffsetY = 0;
    var canvasX = 0;
    var canvasY = 0;
    var currentElement = this;

    do {
        totalOffsetX += currentElement.offsetLeft;
        totalOffsetY += currentElement.offsetTop;
    }
    while (currentElement = currentElement.offsetParent)

    canvasX = event.pageX - totalOffsetX;
    canvasY = event.pageY - totalOffsetY;

    // Fix for variable canvas width
    canvasX = Math.round( canvasX * (this.width / this.offsetWidth) );
    canvasY = Math.round( canvasY * (this.height / this.offsetHeight) );

    return {x:canvasX, y:canvasY}
}

这里是一个简化的解决方案(这并不适用于边框/滚动):

function click(event) {
    const bound = event.target.getBoundingClientRect();

    const xMult = bound.width / can.width;
    const yMult = bound.height / can.height;

    return {
        x: Math.floor(event.offsetX / xMult),
        y: Math.floor(event.offsetY / yMult),
    };
}

更新(5/5/16):应该使用patriques的答案，因为它既简单又可靠。

Since the canvas isn't always styled relative to the entire page, the canvas.offsetLeft/Top doesn't always return what you need. It will return the number of pixels it is offset relative to its offsetParent element, which can be something like a div element containing the canvas with a position: relative style applied. To account for this you need to loop through the chain of offsetParents, beginning with the canvas element itself. This code works perfectly for me, tested in Firefox and Safari but should work for all.

function relMouseCoords(event){
    var totalOffsetX = 0;
    var totalOffsetY = 0;
    var canvasX = 0;
    var canvasY = 0;
    var currentElement = this;

    do{
        totalOffsetX += currentElement.offsetLeft - currentElement.scrollLeft;
        totalOffsetY += currentElement.offsetTop - currentElement.scrollTop;
    }
    while(currentElement = currentElement.offsetParent)

    canvasX = event.pageX - totalOffsetX;
    canvasY = event.pageY - totalOffsetY;

    return {x:canvasX, y:canvasY}
}
HTMLCanvasElement.prototype.relMouseCoords = relMouseCoords;

最后一行可以方便地获取相对于canvas元素的鼠标坐标。要得到有用的坐标只需要

coords = canvas.relMouseCoords(event);
canvasX = coords.x;
canvasY = coords.y;

现代浏览器现在可以帮你处理这个。Chrome, IE9和Firefox支持这样的offsetX/Y，从点击处理程序传入事件。

function getRelativeCoords(event) {
    return { x: event.offsetX, y: event.offsetY };
}

大多数现代浏览器也支持layerX/Y，但是Chrome和IE使用layerX/Y作为页面点击的绝对偏移量，包括边距、填充等。在Firefox中，layerX/Y和offsetX/Y是等价的，但是offset之前并不存在。所以，为了兼容稍微老一点的浏览器，你可以使用:

function getRelativeCoords(event) {
    return { x: event.offsetX || event.layerX, y: event.offsetY || event.layerY };
}

在Prototype中，使用cumulativeOffset()执行上面Ryan Artecona提到的递归求和。

http://www.prototypejs.org/api/element/cumulativeoffset