我通过使用pip安装MySQL-python库克服了同样的问题。当我第一次在settings.py中更改数据库设置并执行makemigrations命令时，您可以看到控制台上显示的消息(解决方案如下消息所示，请参阅)。

  (vir_env) admins-MacBook-Pro-3:src admin$ python manage.py makemigrations
Traceback (most recent call last):
  File "manage.py", line 10, in <module>
    execute_from_command_line(sys.argv)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/core/management/__init__.py", line 338, in execute_from_command_line
    utility.execute()
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/core/management/__init__.py", line 312, in execute
    django.setup()
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/__init__.py", line 18, in setup
    apps.populate(settings.INSTALLED_APPS)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/apps/registry.py", line 108, in populate
    app_config.import_models(all_models)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/apps/config.py", line 198, in import_models
    self.models_module = import_module(models_module_name)
  File "/usr/local/Cellar/python/2.7.12_1/Frameworks/Python.framework/Versions/2.7/lib/python2.7/importlib/__init__.py", line 37, in import_module
    __import__(name)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/contrib/auth/models.py", line 41, in <module>
    class Permission(models.Model):
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/models/base.py", line 139, in __new__
    new_class.add_to_class('_meta', Options(meta, **kwargs))
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/models/base.py", line 324, in add_to_class
    value.contribute_to_class(cls, name)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/models/options.py", line 250, in contribute_to_class
    self.db_table = truncate_name(self.db_table, connection.ops.max_name_length())
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/__init__.py", line 36, in __getattr__
    return getattr(connections[DEFAULT_DB_ALIAS], item)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/utils.py", line 240, in __getitem__
    backend = load_backend(db['ENGINE'])
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/utils.py", line 111, in load_backend
    return import_module('%s.base' % backend_name)
  File "/usr/local/Cellar/python/2.7.12_1/Frameworks/Python.framework/Versions/2.7/lib/python2.7/importlib/__init__.py", line 37, in import_module
    __import__(name)
  File "/Users/admin/Desktop/SetUp1/vir_env/lib/python2.7/site-packages/django/db/backends/mysql/base.py", line 27, in <module>
    raise ImproperlyConfigured("Error loading MySQLdb module: %s" % e)
django.core.exceptions.ImproperlyConfigured: Error loading MySQLdb module: No module named MySQLdb

最终我克服了这个问题:

(vir_env) admins-MacBook-Pro-3:src admin$ pip install MySQLdb
Collecting MySQLdb
  Could not find a version that satisfies the requirement MySQLdb (from versions: )
No matching distribution found for MySQLdb
(vir_env) admins-MacBook-Pro-3:src admin$ pip install MySQL-python
Collecting MySQL-python
  Downloading MySQL-python-1.2.5.zip (108kB)
    100% |████████████████████████████████| 112kB 364kB/s 
Building wheels for collected packages: MySQL-python
  Running setup.py bdist_wheel for MySQL-python ... done
  Stored in directory: /Users/admin/Library/Caches/pip/wheels/38/a3/89/ec87e092cfb38450fc91a62562055231deb0049a029054dc62
Successfully built MySQL-python
Installing collected packages: MySQL-python
Successfully installed MySQL-python-1.2.5
(vir_env) admins-MacBook-Pro-3:src admin$ python manage.py makemigrations
No changes detected
(vir_env) admins-MacBook-Pro-3:src admin$ python manage.py migrate
Operations to perform:
  Synchronize unmigrated apps: staticfiles, rest_framework, messages, crispy_forms
  Apply all migrations: admin, contenttypes, sessions, auth, PyApp
Synchronizing apps without migrations:
  Creating tables...
    Running deferred SQL...
  Installing custom SQL...
Running migrations:
  Rendering model states... DONE
  Applying PyApp.0001_initial... OK
  Applying PyApp.0002_auto_20170310_0936... OK
  Applying PyApp.0003_auto_20170310_0953... OK
  Applying PyApp.0004_auto_20170310_0954... OK
  Applying PyApp.0005_auto_20170311_0619... OK
  Applying PyApp.0006_auto_20170311_0622... OK
  Applying PyApp.0007_loraevksensor... OK
  Applying PyApp.0008_auto_20170315_0752... OK
  Applying PyApp.0009_auto_20170315_0753... OK
  Applying PyApp.0010_auto_20170315_0806... OK
  Applying PyApp.0011_auto_20170315_0814... OK
  Applying PyApp.0012_auto_20170315_0820... OK
  Applying PyApp.0013_auto_20170315_0822... OK
  Applying PyApp.0014_auto_20170315_0907... OK
  Applying PyApp.0015_auto_20170315_1041... OK
  Applying PyApp.0016_auto_20170315_1355... OK
  Applying PyApp.0017_auto_20170315_1401... OK
  Applying PyApp.0018_auto_20170331_1348... OK
  Applying PyApp.0019_auto_20170331_1349... OK
  Applying PyApp.0020_auto_20170331_1350... OK
  Applying PyApp.0021_auto_20170331_1458... OK
  Applying PyApp.0022_delete_postoffice... OK
  Applying PyApp.0023_posoffice... OK
  Applying PyApp.0024_auto_20170331_1504... OK
  Applying PyApp.0025_auto_20170331_1511... OK
  Applying contenttypes.0001_initial... OK
  Applying auth.0001_initial... OK
  Applying admin.0001_initial... OK
  Applying contenttypes.0002_remove_content_type_name... OK
  Applying auth.0002_alter_permission_name_max_length... OK
  Applying auth.0003_alter_user_email_max_length... OK
  Applying auth.0004_alter_user_username_opts... OK
  Applying auth.0005_alter_user_last_login_null... OK
  Applying auth.0006_require_contenttypes_0002... OK
  Applying sessions.0001_initial... OK
(vir_env) admins-MacBook-Pro-3:src admin$ 

执行此命令

sudo pip install mysql-python;

现在可以运行命令了。

python manage.py startapp filename;

我是如何让它工作的:

virtualenv -p python3.5 env/test

在找到我的环境后:

pip install pymysql
pip install django

然后，我运行startproject，在manage.py中，我添加了这个:

+ try:
+     import pymysql
+     pymysql.install_as_MySQLdb()
+ except:
+     pass

同时，更新了内部设置:

DATABASES = {
    'default': {
        'ENGINE': 'django.db.backends.mysql',
        'NAME': 'foobar_db',
        'USER': 'foobaruser',
        'PASSWORD': 'foobarpwd',
    }
}

我也有configparser==3.5.0安装在我的virtualenv，不确定这是否是必需的…

希望能有所帮助，

此问题是由于MySQL for Python适配器安装不完整/不正确造成的。具体来说，我必须编辑mysql_config文件的路径，使其指向/usr/local/mysql/bin/mysql_config——本文将更详细地讨论:http://dakrauth.com/blog/entry/python-and-django-setup-mac-os-x-leopard/

我在OSX 10.6.6上遇到了同样的问题。但只是在终端上简单的easy_install mysql-python并不能解决这个问题，因为另一个问题随之而来:

错误:命令'gcc-4.2'失败，退出状态为1。

显然，这个问题是在从XCode3 (OSX 10.6自带)升级到XCode4之后出现的。这个更新的版本删除了对建造ppc拱门的支持。如果是同样的情况，请尝试在easy_install mysql-python之前执行以下操作

sudo bash
export ARCHFLAGS='-arch i386 -arch x86_64'
rm -r build
python setup.py build
python setup.py install

非常感谢Ned Deily提供的解决方案。检查在这里

Mysql_config必须在路径上。在Mac上

export PATH=$PATH:/usr/local/mysql/bin/
pip install MySQL-python