可以，只需使用javascript获取文件，确保将文件作为数据URL读取。解析出base64之前的内容，以实际获得base64编码的数据，然后如果您使用php或任何后端语言，您可以解码base64数据并保存到如下所示的文件中

Javascript:
var reader = new FileReader();
reader.onloadend = function ()
{
  dataToBeSent = reader.result.split("base64,")[1];
  $.post(url, {data:dataToBeSent});
}
reader.readAsDataURL(this.files[0]);


PHP:
    file_put_contents('my.pdf', base64_decode($_POST["data"]));

当然，你可能会想做一些验证，比如检查你正在处理的文件类型之类的事情，但这是一个想法。

如许多答案所示，使用FormData是一种方法。这里有一些代码非常适合这个目的。我也同意嵌套ajax块以完成复杂环境的意见。通过包括e.PreventDefault（）；根据我的经验，使代码更易于跨浏览器兼容。

    $('#UploadB1').click(function(e){        
    e.preventDefault();

    if (!fileupload.valid()) {
        return false;            
    }

    var myformData = new FormData();        
    myformData.append('file', $('#uploadFile')[0].files[0]);

    $("#UpdateMessage5").html("Uploading file ....");
    $("#UpdateMessage5").css("background","url(../include/images/loaderIcon.gif) no-repeat right");

    myformData.append('mode', 'fileUpload');
    myformData.append('myid', $('#myid').val());
    myformData.append('type', $('#fileType').val());
    //formData.append('myfile', file, file.name); 

    $.ajax({
        url: 'include/fetch.php',
        method: 'post',
        processData: false,
        contentType: false,
        cache: false,
        data: myformData,
        enctype: 'multipart/form-data',
        success: function(response){
            $("#UpdateMessage5").html(response); //.delay(2000).hide(1); 
            $("#UpdateMessage5").css("background","");

            console.log("file successfully submitted");
        },error: function(){
            console.log("not okay");
        }
    });
});

<input class="form-control cu-b-border" type="file" id="formFile">
<img id="myImg" src="#">

在js中

<script>
    var formData = new FormData();
    formData.append('file', $('#formFile')[0].files[0]);
    $.ajax({
        type: "POST",
        url: '/GetData/UploadImage',
        data: formData,
        processData: false, // tell jQuery not to process the data
        contentType: false, // tell jQuery not to set contentType
        success: function (data) {
            console.log(data);
            $('#myImg').attr('src', data);
        },
        error: function (xhr, ajaxOptions, thrownError) {
        }
    })
</script>

在控制器中

public ActionResult UploadImage(HttpPostedFileBase file)
        {
            string filePath = "";
            if (file != null)
            {
                string path = "/uploads/Temp/";
                if (!Directory.Exists(Server.MapPath("~" + path)))
                {
                    Directory.CreateDirectory(Server.MapPath("~" + path));
                }
                filePath = FileUpload.SaveUploadedFile(file, path);
            }
            
            return Json(filePath, JsonRequestBehavior.AllowGet);
        }

使用隐藏的iframe并将表单的目标设置为该iframe的名称。这样，当提交表单时，只会刷新iframe。为iframe的加载事件注册一个事件处理程序，以解析响应。

您可以使用ajaxSubmit方法，如下所示：）当您选择需要上传到服务器的文件时，表单将提交到服务器：）

$(document).ready(function () {
    var options = {
    target: '#output',   // target element(s) to be updated with server response
    timeout: 30000,
    error: function (jqXHR, textStatus) {
            $('#output').html('have any error');
            return false;
        }
    },
    success: afterSuccess,  // post-submit callback
    resetForm: true
            // reset the form after successful submit
};

$('#idOfInputFile').on('change', function () {
    $('#idOfForm').ajaxSubmit(options);
    // always return false to prevent standard browser submit and page navigation
    return false;
});
});

通过ajax上传文件不再需要Iframes。我最近自己做过。查看以下页面：

使用AJAX和jQuery上传HTML5文件

http://dev.w3.org/2006/webapi/FileAPI/#FileReader-界面

更新了答案并进行了清理。使用getSize函数检查大小或使用getType函数检查类型。添加了progressbar html和css代码。

var Upload = function (file) {
    this.file = file;
};

Upload.prototype.getType = function() {
    return this.file.type;
};
Upload.prototype.getSize = function() {
    return this.file.size;
};
Upload.prototype.getName = function() {
    return this.file.name;
};
Upload.prototype.doUpload = function () {
    var that = this;
    var formData = new FormData();

    // add assoc key values, this will be posts values
    formData.append("file", this.file, this.getName());
    formData.append("upload_file", true);

    $.ajax({
        type: "POST",
        url: "script",
        xhr: function () {
            var myXhr = $.ajaxSettings.xhr();
            if (myXhr.upload) {
                myXhr.upload.addEventListener('progress', that.progressHandling, false);
            }
            return myXhr;
        },
        success: function (data) {
            // your callback here
        },
        error: function (error) {
            // handle error
        },
        async: true,
        data: formData,
        cache: false,
        contentType: false,
        processData: false,
        timeout: 60000
    });
};

Upload.prototype.progressHandling = function (event) {
    var percent = 0;
    var position = event.loaded || event.position;
    var total = event.total;
    var progress_bar_id = "#progress-wrp";
    if (event.lengthComputable) {
        percent = Math.ceil(position / total * 100);
    }
    // update progressbars classes so it fits your code
    $(progress_bar_id + " .progress-bar").css("width", +percent + "%");
    $(progress_bar_id + " .status").text(percent + "%");
};

如何使用Upload类

//Change id to your id
$("#ingredient_file").on("change", function (e) {
    var file = $(this)[0].files[0];
    var upload = new Upload(file);

    // maby check size or type here with upload.getSize() and upload.getType()

    // execute upload
    upload.doUpload();
});

Progressbar html代码

<div id="progress-wrp">
    <div class="progress-bar"></div>
    <div class="status">0%</div>
</div>

Progressbar css代码

#progress-wrp {
  border: 1px solid #0099CC;
  padding: 1px;
  position: relative;
  height: 30px;
  border-radius: 3px;
  margin: 10px;
  text-align: left;
  background: #fff;
  box-shadow: inset 1px 3px 6px rgba(0, 0, 0, 0.12);
}

#progress-wrp .progress-bar {
  height: 100%;
  border-radius: 3px;
  background-color: #f39ac7;
  width: 0;
  box-shadow: inset 1px 1px 10px rgba(0, 0, 0, 0.11);
}

#progress-wrp .status {
  top: 3px;
  left: 50%;
  position: absolute;
  display: inline-block;
  color: #000000;
}