如果你在Proguard中使用minifyEnabled，你可能不需要启用multi-dex。我同意MG Developer的观点，如果可能的话，你应该尽量避免使用多重索引。我的解决方案是只对调试版本启用multi-dex。minifyEnabled解决了发布版本的问题

buildTypes {
    release {
        minifyEnabled true
        proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro'
    }
    debug {
        // getting error: Cannot fit requested classes in a single dex file.  # methods: 65537 > 65536
        // https://developer.android.com/studio/build/multidex
        // minifyEnabled true (used with release) will fix this by getting rid of unused method calls, but this will hide debugging info on crash
        multiDexEnabled true
    }
}

Goto构建。Gradle的应用程序文件夹， 设置minSdkVersion为21

保存并运行您的应用程序，它应该没有dex错误现在运行

我在颤振项目中使用了以下解决方案:

志愿者项目/ app /构建开放。Gradle并添加以下行:

android {
    ...

    defaultConfig {
        ...
        
        minSdkVersion 21
        multiDexEnabled true
    }
}

then

dependencies {
    ...

    implementation 'com.android.support:multidex:1.0.3'
}

如果你已经迁移到AndroidX，你会想要这样:

dependencies {
    ...

    implementation 'androidx.multidex:multidex:2.0.1'
}

这个解决方案对我很有效。谢谢你的提问。

我为我的项目找到了这个解决方案 我只是将最低SDK版本设置为21，这就解决了我的问题

android {
    defaultConfig {
        ...
        minSdkVersion 21 //set the minimum sdk version 21
        targetSdkVersion 29
    }
    ...
}

如果您的minSdkVersion为21或更高，则默认启用multidex，并且您不需要multidex支持库。 阅读更多关于multidex https://developer.android.com/studio/build/multidex.html

只需将此代码添加到应用程序或模块的build.gradle中即可

android {
    defaultConfig {
        ...
        
        multiDexEnabled true <------ * here
    }
    ...
}

修改应用程序或模块的build.gradle

android {
    defaultConfig {
        ...
        minSdkVersion 21 <----- *here
        targetSdkVersion 26
        multiDexEnabled true <------ *here
    }
    ...
}

根据官方文件

Multidex support for Android 5.0 and higher Android 5.0 (API level 21) and higher uses a runtime called ART which natively supports loading multiple DEX files from APK files. ART performs pre-compilation at app install time which scans for classesN.dex files and compiles them into a single .oat file for execution by the Android device. Therefore, if your minSdkVersion is 21 or higher, you do not need the multidex support library. For more information on the Android 5.0 runtime, read ART and Dalvik.

https://developer.android.com/studio/build/multidex