详见诺亚的回答

//Option A.) set to null
some_var = null;

//Option B.) set to undefined
some_var = undefined;

//Option C.) remove/delete the variable reference
delete obj.some_var
//if your variable was defined as a global, you'll need to
//qualify the reference with 'window'
delete window.some_var;

引用:

MDN删除API 在严格模式下删除非限定变量名时出现MDN SyntaxError

TLDR:简单定义的变量(没有var, let, const)可以用delete删除。如果你使用var, let, const -它们不能被delete或Reflect.deleteProperty删除。

Chrome 55:

simpleVar = "1";
"1"
delete simpleVar;
true
simpleVar;
VM439:1 Uncaught ReferenceError: simpleVar is not defined
    at <anonymous>:1:1
(anonymous) @ VM439:1
var varVar = "1";
undefined
delete varVar;
false
varVar;
"1"
let letVar = "1";
undefined
delete letVar;
true
letVar;
"1"
const constVar="1";
undefined
delete constVar;
true
constVar;
"1"
Reflect.deleteProperty (window, "constVar");
true
constVar;
"1"
Reflect.deleteProperty (window, "varVar");
false
varVar;
"1"
Reflect.deleteProperty (window, "letVar");
true
letVar;
"1"

Firefox Nightly 53.0a1显示相同的行为。

详见诺亚的回答

//Option A.) set to null
some_var = null;

//Option B.) set to undefined
some_var = undefined;

//Option C.) remove/delete the variable reference
delete obj.some_var
//if your variable was defined as a global, you'll need to
//qualify the reference with 'window'
delete window.some_var;

引用:

MDN删除API 在严格模式下删除非限定变量名时出现MDN SyntaxError

如果你在第一次使用时声明了一个变量(使用var x;)，你就不能删除它。 但是，如果你的变量x第一次出现在脚本中没有声明，那么你可以使用delete操作符(delete x;)，你的变量将被删除，这与删除数组的元素或删除对象的属性非常相似。

与简单的属性相比，变量具有属性[[可配置的]]，这意味着不可能通过删除操作符删除变量。

但是，有一个执行上下文不受此规则的影响。它是eval上下文:其中没有为变量设置[[Configurable]]属性。

注意，delete操作成功时返回true。

2021年更新:在Chrome 88和Firefox 84上测试:

implicit_global = 1;
delete implicit_global; // true

window.explicit_global = 1;
delete explicit_global; // true

const _object = {property: 1};
delete _object.property; // true

function_set = function() {};
delete function_set; // true

function function_declaration() {};
delete function_declaration; // false

(function () {
    var _var = 1;
    console.log(delete _var); // false
    console.log(_var); // 1
})()

(function () {
    let _let = 1;
    console.log(delete _let); // false
    console.log(_let); // 1
})()

(function () {
    const _const = 1;
    console.log(delete _const); // false
    console.log(_const); // 1
})()

由于浏览器更新，此答案的先前编辑已不再相关。