乔纳森·M的代码对我来说太复杂了，所以我重写了它，在Firefox v30上获得了30%的速度提升，在Chrome v35上获得了60%的速度提升(http://jsperf.com/number-formating2):

Number.prototype.formatNumber = function(decPlaces, thouSeparator, decSeparator) {
    decPlaces = isNaN(decPlaces = Math.abs(decPlaces)) ? 2 : decPlaces;
    decSeparator = decSeparator == undefined ? "." : decSeparator;
    thouSeparator = thouSeparator == undefined ? "," : thouSeparator;

    var n = this.toFixed(decPlaces);
    if (decPlaces) {
        var i = n.substr(0, n.length - (decPlaces + 1));
        var j = decSeparator + n.substr(-decPlaces);
    } else {
        i = n;
        j = '';
    }

    function reverse(str) {
        var sr = '';
        for (var l = str.length - 1; l >= 0; l--) {
            sr += str.charAt(l);
        }
        return sr;
    }

    if (parseInt(i)) {
        i = reverse(reverse(i).replace(/(\d{3})(?=\d)/g, "$1" + thouSeparator));
    }
    return i + j;
};

用法：

var sum = 123456789.5698;
var formatted = '$' + sum.formatNumber(2, ',', '.'); // "$123,456,789.57"

我主要基于VisionN的回答：

function format (val) {
  val = (+val).toLocaleString();
  val = (+val).toFixed(2);
  val += "";
  return val.replace(/(\d)(?=(\d{3})+(?:\.\d+)?$)/g, "$1" + format.thousands);
}

(function (isUS) {
  format.decimal =   isUS ? "." : ",";
  format.thousands = isUS ? "," : ".";
}(("" + (+(0.00).toLocaleString()).toFixed(2)).indexOf(".") > 0));

我用输入进行了测试：

[   ""
  , "1"
  , "12"
  , "123"
  , "1234"
  , "12345"
  , "123456"
  , "1234567"
  , "12345678"
  , "123456789"
  , "1234567890"
  , ".12"
  , "1.12"
  , "12.12"
  , "123.12"
  , "1234.12"
  , "12345.12"
  , "123456.12"
  , "1234567.12"
  , "12345678.12"
  , "123456789.12"
  , "1234567890.12"
  , "1234567890.123"
  , "1234567890.125"
].forEach(function (item) {
  console.log(format(item));
});

得到了这些结果：

0.00
1.00
12.00
123.00
1,234.00
12,345.00
123,456.00
1,234,567.00
12,345,678.00
123,456,789.00
1,234,567,890.00
0.12
1.12
12.12
123.12
1,234.12
12,345.12
123,456.12
1,234,567.12
12,345,678.12
123,456,789.12
1,234,567,890.12
1,234,567,890.12
1,234,567,890.13

只是为了好玩。

以下是将数字转换为货币格式的简短最佳方法：

function toCurrency(amount){
    return amount.replace(/(\d)(?=(\d\d\d)+(?!\d))/g, "$1,");
}

// usage: toCurrency(3939920.3030);

Intl.NumberFormat（国际数字格式）

var number = 3500;
alert(new Intl.NumberFormat().format(number));
// → "3,500" if in US English locale

或者JavaScript中的PHP的number_format。

适用于所有当前浏览器

使用toLocaleString以货币的语言敏感表示形式格式化货币（使用ISO 4217货币代码）。

(2500).toLocaleString("en-GB", {style: "currency", currency: "GBP", minimumFractionDigits: 2})

avenmore的南非兰特代码片段示例：

console.log（（2500）.toLocaleString（“en-ZA”，｛style:“currency”，currency:“ZAR”，minimumFractionDigits:2｝））//->2 500,00兰特console.log（（2500）.toLocaleString（“en-GB”，｛style:“currency”，currency:“ZAR”，minimumFractionDigits:2｝））//->2500欧元

我喜欢简单：

function formatPriceUSD(price) {
    var strPrice = price.toFixed(2).toString();
    var a = strPrice.split('');

    if (price > 1000000000)
        a.splice(a.length - 12, 0, ',');

    if (price > 1000000)
        a.splice(a.length - 9, 0, ',');

    if (price > 1000)
        a.splice(a.length - 6, 0, ',');

    return '$' + a.join("");
}