Swift 3版本

简单地创建一个UICollectionViewFlowLayout子类并粘贴这个方法。

override func layoutAttributesForElements(in rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
        guard let answer = super.layoutAttributesForElements(in: rect) else { return nil }

        for i in 1..<answer.count {
            let currentAttributes = answer[i]
            let previousAttributes = answer[i - 1]

            let maximumSpacing: CGFloat = 8
            let origin = previousAttributes.frame.maxX

            if (origin + maximumSpacing + currentAttributes.frame.size.width < self.collectionViewContentSize.width && currentAttributes.frame.origin.x > previousAttributes.frame.origin.x) {
                var frame = currentAttributes.frame
                frame.origin.x = origin + maximumSpacing
                currentAttributes.frame = frame
            }
        }

        return answer
}

上面vojtech-vrbka的解决方案是正确的，但它会触发一个警告:

警告:UICollectionViewFlowLayout缓存的帧不匹配索引路径-缓存值:这可能是因为流布局子类layout是修改UICollectionViewFlowLayout返回的属性而没有复制它们

下面的代码应该修复它:

class CustomViewFlowLayout : UICollectionViewFlowLayout {

   let cellSpacing:CGFloat = 4

   override func layoutAttributesForElementsInRect(rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
       let original = super.layoutAttributesForElementsInRect(rect)

       if let original = original {
           let attributes = NSArray.init(array: original, copyItems: true) as! [UICollectionViewLayoutAttributes]

           for (index, attribute) in attributes.enumerate() {
                if index == 0 { continue }
                let prevLayoutAttributes = attributes[index - 1]
                let origin = CGRectGetMaxX(prevLayoutAttributes.frame)
                if(origin + cellSpacing + attribute.frame.size.width < self.collectionViewContentSize().width) {
                    attribute.frame.origin.x = origin + cellSpacing
                }
            }
            return attributes
       }
       return nil
   }
}

我使用monotouch，所以名称和代码会有点不同，但你可以通过确保集合视图的宽度等于(x *单元格宽度)+ (x-1) * MinimumSpacing与x =每行单元格的数量来做到这一点。

只需要根据MinimumInteritemSpacing和Cell的宽度执行以下步骤

1)我们根据单元格大小+当前插入+最小间距计算每行项目的数量

float currentTotalWidth = CollectionView.Frame.Width - Layout.SectionInset.Left - Layout.SectionInset.Right (Layout = flowlayout)
int amountOfCellsPerRow = (currentTotalWidth + MinimumSpacing) / (cell width + MinimumSpacing)

2)现在你有了所有信息来计算集合视图的预期宽度

float totalWidth =(amountOfCellsPerRow * cell width) + (amountOfCellsPerRow-1) * MinimumSpacing

3)所以当前宽度与预期宽度之差为

float difference = currentTotalWidth - totalWidth;

4)现在调整insets(在本例中，我们将其添加到右侧，因此集合视图的左侧位置保持不变

Layout.SectionInset.Right = Layout.SectionInset.Right + difference;

在头文件中定义UICollectionViewDelegateFlowLayout协议。

实现UICollectionViewDelegateFlowLayout协议的如下方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView layout:(UICollectionViewLayout*)collectionViewLayout insetForSectionAtIndex:(NSInteger)section
{
    return UIEdgeInsetsMake(5, 5, 5, 5);
}

点击这里查看苹果文档的UIEdgeInsetMake方法。

我偶然发现了与op类似的问题。不幸的是，接受的答案不适合我，因为collectionView的内容不会正确居中。因此，我提出了一个不同的解决方案，只需要在collectionView中的所有项目都具有相同的宽度，这似乎是问题中的情况:

#define cellSize 90

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView layout:(UICollectionViewLayout *)collectionViewLayout insetForSectionAtIndex:(NSInteger)section {
    float width = collectionView.frame.size.width;
    float spacing = [self collectionView:collectionView layout:collectionViewLayout minimumInteritemSpacingForSectionAtIndex:section];
    int numberOfCells = (width + spacing) / (cellSize + spacing);
    int inset = (width + spacing - numberOfCells * (cellSize + spacing) ) / 2;

    return UIEdgeInsetsMake(0, inset, 0, inset);
}

该代码将确保…minimumInteritemSpacing…将是每个collectionViewCell之间的精确间距，并进一步保证所有的单元格一起将在collectionView

我在Swift 3单元格间距的解决方案，如Instagram:

lazy var collectionView: UICollectionView = {
    let layout = UICollectionViewFlowLayout()
    let cv = UICollectionView(frame: .zero, collectionViewLayout: layout)
    cv.backgroundColor = UIColor.rgb(red: 227, green: 227, blue: 227)
    cv.showsVerticalScrollIndicator = false
    layout.scrollDirection = .vertical
    layout.minimumLineSpacing = 1
    layout.minimumInteritemSpacing = 1
    return cv
}()

func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, sizeForItemAt indexPath: IndexPath) -> CGSize {

    switch UIDevice.current.modelName {
    case "iPhone 4":
        return CGSize(width: 106, height: 106)
    case "iPhone 5":
        return CGSize(width: 106, height: 106)
    case "iPhone 6,7":
        return CGSize(width: 124, height: 124)
    case "iPhone Plus":
        return CGSize(width: 137, height: 137)
    default:
        return CGSize(width: frame.width / 3, height: frame.width / 3)
    }
}

如何编程检测设备: https://stackoverflow.com/a/26962452/6013170