Swift 3版本

简单地创建一个UICollectionViewFlowLayout子类并粘贴这个方法。

override func layoutAttributesForElements(in rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
        guard let answer = super.layoutAttributesForElements(in: rect) else { return nil }

        for i in 1..<answer.count {
            let currentAttributes = answer[i]
            let previousAttributes = answer[i - 1]

            let maximumSpacing: CGFloat = 8
            let origin = previousAttributes.frame.maxX

            if (origin + maximumSpacing + currentAttributes.frame.size.width < self.collectionViewContentSize.width && currentAttributes.frame.origin.x > previousAttributes.frame.origin.x) {
                var frame = currentAttributes.frame
                frame.origin.x = origin + maximumSpacing
                currentAttributes.frame = frame
            }
        }

        return answer
}

上面vojtech-vrbka的解决方案是正确的，但它会触发一个警告:

警告:UICollectionViewFlowLayout缓存的帧不匹配索引路径-缓存值:这可能是因为流布局子类layout是修改UICollectionViewFlowLayout返回的属性而没有复制它们

下面的代码应该修复它:

class CustomViewFlowLayout : UICollectionViewFlowLayout {

   let cellSpacing:CGFloat = 4

   override func layoutAttributesForElementsInRect(rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
       let original = super.layoutAttributesForElementsInRect(rect)

       if let original = original {
           let attributes = NSArray.init(array: original, copyItems: true) as! [UICollectionViewLayoutAttributes]

           for (index, attribute) in attributes.enumerate() {
                if index == 0 { continue }
                let prevLayoutAttributes = attributes[index - 1]
                let origin = CGRectGetMaxX(prevLayoutAttributes.frame)
                if(origin + cellSpacing + attribute.frame.size.width < self.collectionViewContentSize().width) {
                    attribute.frame.origin.x = origin + cellSpacing
                }
            }
            return attributes
       }
       return nil
   }
}

在头文件中定义UICollectionViewDelegateFlowLayout协议。

实现UICollectionViewDelegateFlowLayout协议的如下方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView layout:(UICollectionViewLayout*)collectionViewLayout insetForSectionAtIndex:(NSInteger)section
{
    return UIEdgeInsetsMake(5, 5, 5, 5);
}

点击这里查看苹果文档的UIEdgeInsetMake方法。

试试这个方法:

- (UIEdgeInsets)collectionView:(UICollectionView *)collectionView
                    layout:(UICollectionViewLayout*)collectionViewLayout
    insetForSectionAtIndex:(NSInteger)section {

    UIEdgeInsets insets = UIEdgeInsetsMake(?, ?, ?, ?);

    return insets;
}

故事板的方法

在你的故事板中选择CollectionView，然后进入尺寸检查器，设置单元格和行的最小间距为5

Swift 5编程方式

lazy var collectionView: UICollectionView = {
        let layout = UICollectionViewFlowLayout()
        layout.scrollDirection = .horizontal

        //Provide Width and Height According to your need
        let width = UIScreen.main.bounds.width / 4
        let height = UIScreen.main.bounds.height / 10
        layout.itemSize = CGSize(width: width, height: height)

        //For Adjusting the cells spacing
        layout.minimumInteritemSpacing = 5
        layout.minimumLineSpacing = 5

        return UICollectionView(frame: self.view.frame, collectionViewLayout: layout)
    }()

我有问题与接受的答案，所以我更新了它，这是为我工作:

.h

@interface MaxSpacingCollectionViewFlowLayout : UICollectionViewFlowLayout
@property (nonatomic,assign) CGFloat maxCellSpacing;
@end

.m

@implementation MaxSpacingCollectionViewFlowLayout

- (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect {
    NSArray *attributes = [super layoutAttributesForElementsInRect:rect];

    if (attributes.count <= 0) return attributes;

    CGFloat firstCellOriginX = ((UICollectionViewLayoutAttributes *)attributes[0]).frame.origin.x;

    for(int i = 1; i < attributes.count; i++) {
        UICollectionViewLayoutAttributes *currentLayoutAttributes = attributes[i];
        if (currentLayoutAttributes.frame.origin.x == firstCellOriginX) { // The first cell of a new row
            continue;
        }

        UICollectionViewLayoutAttributes *prevLayoutAttributes = attributes[i - 1];
        CGFloat prevOriginMaxX = CGRectGetMaxX(prevLayoutAttributes.frame);
        if ((currentLayoutAttributes.frame.origin.x - prevOriginMaxX) > self.maxCellSpacing) {
            CGRect frame = currentLayoutAttributes.frame;
            frame.origin.x = prevOriginMaxX + self.maxCellSpacing;
            currentLayoutAttributes.frame = frame;
        }
    }
    return attributes;
}

@end