以下是Swift版本的公认答案:

斯威夫特3:

let font = UIFont.systemFont(ofSize: 16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font],
                                        for: .normal)

斯威夫特2.2:

let font = UIFont.systemFontOfSize(16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font], 
    forState: UIControlState.Normal)

UISegmentedControl的扩展，用于设置字体大小。

extension UISegmentedControl {
    @available(iOS 8.2, *)
    func setFontSize(fontSize: CGFloat) {
            let normalTextAttributes: [NSObject : AnyObject]!
            if #available(iOS 9.0, *) {
                normalTextAttributes = [
                    NSFontAttributeName: UIFont.monospacedDigitSystemFontOfSize(fontSize, weight: UIFontWeightRegular)
                ]
            } else {
                normalTextAttributes = [
                    NSFontAttributeName: UIFont.systemFontOfSize(fontSize, weight: UIFontWeightRegular)
                ]
            }

        self.setTitleTextAttributes(normalTextAttributes, forState: .Normal)
    }
 }

这里我已经更新了iOS8

[[UISegmentedControl appearance] setTitleTextAttributes:[NSDictionary dictionaryWithObjectsAndKeys:[UIFont fontWithName:@"STHeitiSC-Medium" size:13.0], NSFontAttributeName, nil] forState:UIControlStateNormal];

XCode 8.1, Swift 3

import UIKit
class ViewController: UIViewController {
    override func viewDidLoad() {
        super.viewDidLoad()
        UISegmentedControl.appearance().setTitleTextAttributes(NSDictionary(objects: [UIFont.systemFont(ofSize: 24.0)], 
        forKeys: [NSFontAttributeName as NSCopying]) as? [AnyHashable : Any], 
        for: UIControlState.normal)
    }
}

只需要改变数值(ofSize: 24.0)

丹尼尔指给我正确的路。我是这样用的-

float scaleFactor = 0.8f;

UISegmentedControl *segmentedControl = [[UISegmentedControl alloc]
initWithFrame:CGRectMake(10, 70, 300/scaleFactor,35)];

[segmentedControl insertSegmentWithTitle:@"..." atIndex:0 animated:NO];
[segmentedControl insertSegmentWithTitle:@"..." atIndex:1 animated:NO];
[segmentedControl insertSegmentWithTitle:@"..." atIndex:2 animated:NO];

segmentedControl.transform = CGAffineTransformMakeScale(scaleFactor, 1);
CGPoint segmentedControlCenter = segmentedControl.center;
segmentedControlCenter.x = self.center.x;
segmentedControl.center = segmentedControlCenter;

在swift 5中，

let font = UIFont.systemFont(ofSize: 16)
UISegmentedControl.appearance().setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)