Before changing the web.config file, I would check that the .NET Framework version that you are using is exactly (I mean it, 4.5 != 4.5.2) the same compared to your GoDaddy settings (ASP.Net settings in your Plesk panel). That should automatically change your web.config file to the correct framework. Also notice that for now (January '16), GoDaddy works with ASP.Net 3.5 and 4.5.2. To use 4.5.2 with Visual Studio it has to be 2012 or newer, and if not 2015, you must download and install the .NET Framework 4.5.2 Developer Package. If still not working, then yes, your next step should be enabling detailed error reporting so you can debug it.

Before changing the web.config file, I would check that the .NET Framework version that you are using is exactly (I mean it, 4.5 != 4.5.2) the same compared to your GoDaddy settings (ASP.Net settings in your Plesk panel). That should automatically change your web.config file to the correct framework. Also notice that for now (January '16), GoDaddy works with ASP.Net 3.5 and 4.5.2. To use 4.5.2 with Visual Studio it has to be 2012 or newer, and if not 2015, you must download and install the .NET Framework 4.5.2 Developer Package. If still not working, then yes, your next step should be enabling detailed error reporting so you can debug it.

确保您的帐户使用IIS 7。有关详细信息，请参见自定义Windows主机托管帐户上的IIS设置。 请按照Windows IIS 7托管帐户上更改管道模式的说明进行操作。选择“集成管道模式”。 在“项目参考”部分中，将以下程序集的“本地复制”设置为“True”:

System.Web.Abstractions
System.Web.Helpers
System.Web.Routing
System.Web.Mvc
System.Web.WebPages

将以下程序集添加到项目中，然后将“本地复制”设置为“True”:

Microsoft.Web.Infrastructure
System.Web.Razor
System.Web.WebPages.Deployment
System.Web.WebPages.Razor
Publish your application.

如果在物理主目录上没有足够的权限(即IIS_IUSRS没有访问权限)，IIS也会报告状态码500而没有任何事件日志提示。

对于iis10，除了更改customErrors=Off来显示错误内容外，还有一个额外的步骤要做。

<system.web>
   <customErrors mode="Off" />
</system.web>
<system.webServer>
   <httpErrors existingResponse="PassThrough" errorMode="Detailed"/>
</system.webServer>

Raul在这个链接中回答了这个问题:关闭IIS8自定义错误

有时，原因可能是您的.dll程序集没有在服务器上正确注册。

例如，您可以在安装了Office的本地机器上成功运行c# Excel web应用程序，但在服务器部署时得到500错误，因为服务器上没有安装Office套件，因此您得到服务器错误。